Neutrophil Specific Antigen 1 (NB1)

[Edit]

CD177; HNA2A; PRV1; HNA-2A; NB1 GP; Polycythemia Rubra Vera 1; Human neutrophil alloantigen 2a; Polycythemia rubra vera protein 1

Neutrophil Specific Antigen 1 (NB1)

NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia .

Independently, Kissel et al. (2001) cloned and characterized NB1, which they also referred to as CD177 and HNA2A. They obtained the cDNA after purification and microsequence analysis of NB1 protein from normal resting granulocytes. Kissel et al. (2001) noted amino acid differences between the PRV1 (Temerinac et al., 2000) and NB1 sequences at positions 3, 119, 323, and 379 and suggested that 2 different, highly homologous genes may exist.By genomic sequence analysis and PCR, Kissel et al. (2002) determined that the NB1 gene contains 9 exons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA943Hu01 Recombinant Neutrophil Specific Antigen 1 (NB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA943Hu01 Polyclonal Antibody to Neutrophil Specific Antigen 1 (NB1) WB; IHC; ICC; IP.
MAA943Hu21 Monoclonal Antibody to Neutrophil Specific Antigen 1 (NB1) WB; IHC; ICC; IP.
MAA943Hu22 Monoclonal Antibody to Neutrophil Specific Antigen 1 (NB1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Neutrophil Specific Antigen 1 (NB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neutrophil Specific Antigen 1 (NB1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA943Mu01 Recombinant Neutrophil Specific Antigen 1 (NB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA943Mu01 Polyclonal Antibody to Neutrophil Specific Antigen 1 (NB1) WB; IHC; ICC; IP.
LAA943Mu71 Biotin-Linked Polyclonal Antibody to Neutrophil Specific Antigen 1 (NB1) WB; IHC; ICC.
Assay Kits SEA943Mu ELISA Kit for Neutrophil Specific Antigen 1 (NB1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neutrophil Specific Antigen 1 (NB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neutrophil Specific Antigen 1 (NB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neutrophil Specific Antigen 1 (NB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neutrophil Specific Antigen 1 (NB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neutrophil Specific Antigen 1 (NB1) ELISA Kit Customized Service Offer
  1. "Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera."Blood 95:2569-2576(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular basis of the neutrophil glycoprotein NB1 (CD177) involved in the pathogenesis of immunenneutropenia and transfusion reactions."Eur. J. Immunol. 31:1301-1309(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular basis of NB1 (HNA-2a, CD177) deficiency."Blood 99:4231-4233(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera."Blood 100:2441-2448(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Overexpression of the polycythemia rubra vera-1 gene in essential thrombocythemia."J. Clin. Oncol. 20:4249-4254(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP-neutrophils from NB1 GP-expressing individuals and association of low expression with NB1 gene polymorphisms."Blood 102:731-733(2003) [PubMed] [Europe PMC] [Abstract]
  10. "CD177 polymorphisms: correlation between high-frequency single nucleotide polymorphisms and neutrophil surface protein expression."Transfusion 44:77-82(2004) [PubMed] [Europe PMC] [Abstract]