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The is the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.
The 'DRD4 long' variant, or more specifically the 7 repeat (7R), has been loosely linked to a susceptibility for developing ADHD and other psychological traits and disorders, like autism.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Dopamine Receptor D4 (DRD4) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Dopamine Receptor D4 (DRD4) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Dopamine Receptor D4 (DRD4) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Dopamine Receptor D4 (DRD4) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Dopamine Receptor D4 (DRD4) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Dopamine Receptor D4 (DRD4) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Dopamine Receptor D4 (DRD4) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Dopamine Receptor D4 (DRD4) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Dopamine Receptor D4 (DRD4) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Dopamine Receptor D4 (DRD4) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA925Ra01 | Recombinant Dopamine Receptor D4 (DRD4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPA925Ra61 | Eukaryotic Dopamine Receptor D4 (DRD4) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| EPA925Ra62 | Eukaryotic Dopamine Receptor D4 (DRD4) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA925Ra01 | Polyclonal Antibody to Dopamine Receptor D4 (DRD4) | WB; IHC; ICC; IP. |
| MAA925Ra21 | Monoclonal Antibody to Dopamine Receptor D4 (DRD4) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA925Ra | ELISA Kit for Dopamine Receptor D4 (DRD4) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rhesus monkey (Simian)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Dopamine Receptor D4 (DRD4) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Dopamine Receptor D4 (DRD4) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Dopamine Receptor D4 (DRD4) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Dopamine Receptor D4 (DRD4) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Dopamine Receptor D4 (DRD4) | ELISA Kit Customized Service Offer |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Dopamine Receptor D4 (DRD4) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Dopamine Receptor D4 (DRD4) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Dopamine Receptor D4 (DRD4) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Dopamine Receptor D4 (DRD4) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Dopamine Receptor D4 (DRD4) | ELISA Kit Customized Service Offer |
- "Multiple dopamine D4 receptor variants in the human population."Nature 358:149-152(1992) [PubMed] [Europe PMC] [Abstract]
- "Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine."Nature 350:610-614(1991) [PubMed] [Europe PMC] [Abstract]
- "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
- "A hypervariable segment in the human dopamine receptor D4 (DRD4) gene."Hum. Mol. Genet. 2:767-773(1993) [PubMed] [Europe PMC] [Abstract]
- "Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes."Mol. Pharmacol. 46:364-373(1994) [PubMed] [Europe PMC] [Abstract]
- "Modulation of postendocytic sorting of G protein-coupled receptors."Science 297:615-620(2002) [PubMed] [Europe PMC] [Abstract]
- "BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase."J. Biol. Chem. 283:11083-11096(2008) [PubMed] [Europe PMC] [Abstract]
- "The dopamine D(4) receptor, the ultimate disordered protein."J. Recept. Signal Transduct. 30:331-336(2010) [PubMed] [Europe PMC] [Abstract]
- "KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation."Cell. Signal. 22:900-913(2010) [PubMed] [Europe PMC] [Abstract]
- "Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions."Biochem. Biophys. Res. Commun. 404:928-934(2011) [PubMed] [Europe PMC] [Abstract]
- "Molecular modelling of D2-like dopamine receptors."Biochem. J. 287:277-282(1992) [PubMed] [Europe PMC] [Abstract]
- "Dopamine D4 receptor variant, D4-glycine-194, in Africans, but not in Caucasians: no association with schizophrenia."Am. J. Med. Genet. 54:384-390(1994) [PubMed] [Europe PMC] [Abstract]