≡

Pulmonary Surfactant Associated Protein A1 (SFTPA1)

[Edit]

PRL; SFTPA; PSAP; PSPA; SFTP; SPA; COLEC4; PSP-A; SFTP1; SFTPA1B; SP-A1; Collectin-4; Alveolar proteinosis protein; 35 kDa pulmonary surfactant-associated protein; Surfactant Associated Protein A

Pulmonary Surfactant Associated Protein A1 (SFTPA1)
CCC A890
HGNC 10798
MGI 109518
PubMed 11149893
RGD 3665
UniProt Q8IWL2
Wiki Sftp1

SP-A (PRL) is a peptide hormone primarily associated with lactation. In breastfeeding, the infant suckling the teat stimulates the production of SP-A, which fills the breast with milk (lactogenesis) in preparation for the next feed. Oxytocin, a similar hormone, is also released, which triggers milk let-down. SP-A (PRL) is a polypeptide hormone secreted by anterior pituitary of both male and female. Release of SP-A is controlled by a complex neuroendocrine reflex initiated by a tactile stimulus and regulated by hypothalamic releasing and inhibition. Genetic variations in SFTPA1 are associated with respiratory distress syndrome in premature infants (RDS) ; also known as RDS in prematurity. RDS in the newborn is the main cause of mortality and morbidity in premature infants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA890Hu02 Recombinant Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA890Hu61 Eukaryotic Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
APA890Hu61 Active Pulmonary Surfactant Associated Protein A1 (SFTPA1) Cell culture; Activity Assays.
Antibodies MAA890Hu22 Monoclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB,IHC
LAA890Hu81 FITC-Linked Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IF.
LAA890Hu71 Biotin-Linked Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC.
PAA890Hu02 Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC
PAA890Hu01 Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IP.
MAA890Hu21 Monoclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IP.
Assay Kits SEA890Hu ELISA Kit for Pulmonary Surfactant Associated Protein A1 (SFTPA1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA890Hu CLIA Kit for Pulmonary Surfactant Associated Protein A1 (SFTPA1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA890Mu01 Recombinant Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA890Mu02 Recombinant Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA890Mu61 Eukaryotic Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA890Mu03 Recombinant Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA890Mu04 Recombinant Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
APA890Mu61 Active Pulmonary Surfactant Associated Protein A1 (SFTPA1) Cell culture; Activity Assays.
Antibodies PAA890Mu01 Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IP.
PAA890Mu02 Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IP.
Assay Kits SEA890Mu ELISA Kit for Pulmonary Surfactant Associated Protein A1 (SFTPA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA890Ra01 Recombinant Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA890Ra61 Eukaryotic Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
APA890Ra61 Active Pulmonary Surfactant Associated Protein A1 (SFTPA1) Cell culture; Activity Assays.
Antibodies PAA890Ra01 Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IP.
MAA890Ra21 Monoclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IP.
Assay Kits SEA890Ra ELISA Kit for Pulmonary Surfactant Associated Protein A1 (SFTPA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA890Ca01 Recombinant Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA890Ca01 Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IP.
MAA890Ca21 Monoclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IP.
Assay Kits SEA890Ca ELISA Kit for Pulmonary Surfactant Associated Protein A1 (SFTPA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA890Po01 Recombinant Pulmonary Surfactant Associated Protein A1 (SFTPA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA890Po01 Polyclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IP.
MAA890Po21 Monoclonal Antibody to Pulmonary Surfactant Associated Protein A1 (SFTPA1) WB; IHC; ICC; IP.
Assay Kits SEA890Po ELISA Kit for Pulmonary Surfactant Associated Protein A1 (SFTPA1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation and characterization of the human pulmonary surfactant apoprotein gene."Nature 317:361-363(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and characterization of cDNA clones for the 35-kDa pulmonary surfactant-associated protein."J. Biol. Chem. 261:9029-9033(1986) [PubMed] [Europe PMC] [Abstract]
  3. "Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene."Am. J. Physiol. 299:L523-L534(2010) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Studies of the structure of lung surfactant protein SP-A."Am. J. Physiol. 257:L421-L429(1989) [PubMed] [Europe PMC] [Abstract]
  8. "Genetics of the hydrophilic surfactant proteins A and D."Biochim. Biophys. Acta 1408:312-322(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Association between the surfactant protein A (SP-A) gene locus and respiratory-distress syndrome in the Finnish population."Am. J. Hum. Genet. 66:1569-1579(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis."Hum. Genet. 113:542-550(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer."Am. J. Hum. Genet. 84:52-59(2009) [PubMed] [Europe PMC] [Abstract]