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Carbonic Anhydrase I (CA1)

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CA-I; CAI; Car1; CAB; Carbonic anhydrase B; Carbonate dehydratase I

Carbonic Anhydrase I (CA1)
CCC A875
HGNC 1368
MGI 88268
PubMed 9336012
RGD 1309780
UniProt P00915
Wiki CA1_(gene

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including cellular respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid.They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature.CA I is the major form of the enzyme in human red cells. They found that the protein consists of 260 amino acids.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA875Hu01 Recombinant Carbonic Anhydrase I (CA1) Positive Control; Immunogen; SDS-PAGE; WB.
APA875Hu01 Active Carbonic Anhydrase I (CA1) Cell culture; Activity Assays.
Antibodies PAA875Hu01 Polyclonal Antibody to Carbonic Anhydrase I (CA1) WB; IHC; ICC; IP.
MAA875Hu22 Monoclonal Antibody to Carbonic Anhydrase I (CA1) WB; IHC; ICC; IP.
LAA875Hu71 Biotin-Linked Polyclonal Antibody to Carbonic Anhydrase I (CA1) WB; IHC; ICC.
LAA875Hu81 FITC-Linked Polyclonal Antibody to Carbonic Anhydrase I (CA1) WB; IHC; ICC; IF.
Assay Kits SEA875Hu ELISA Kit for Carbonic Anhydrase I (CA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA875Mu01 Recombinant Carbonic Anhydrase I (CA1) Positive Control; Immunogen; SDS-PAGE; WB.
APA875Mu01 Active Carbonic Anhydrase I (CA1) Cell culture; Activity Assays.
Antibodies PAA875Mu01 Polyclonal Antibody to Carbonic Anhydrase I (CA1) WB; IHC; ICC; IP.
LAA875Mu71 Biotin-Linked Polyclonal Antibody to Carbonic Anhydrase I (CA1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Carbonic Anhydrase I (CA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonic Anhydrase I (CA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbonic Anhydrase I (CA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbonic Anhydrase I (CA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbonic Anhydrase I (CA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbonic Anhydrase I (CA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonic Anhydrase I (CA1) ELISA Kit Customized Service Offer
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  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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  18. "Crystal structure of human erythrocyte carbonic anhydrase B. Three-dimensional structure at a nominal 2.2-A resolution."Proc. Natl. Acad. Sci. U.S.A. 72:51-55(1975) [PubMed] [Europe PMC] [Abstract]
  19. "Structure, refinement, and function of carbonic anhydrase isozymes: refinement of human carbonic anhydrase I."Ann. N. Y. Acad. Sci. 429:49-60(1984) [PubMed] [Europe PMC] [Abstract]
  20. "Differences in anionic inhibition of human carbonic anhydrase I revealed from the structures of iodide and gold cyanide inhibitor complexes."Acta Crystallogr. D 50:731-738(1994) [PubMed] [Europe PMC] [Abstract]
  21. "Enzyme-substrate interactions. Structure of human carbonic anhydrase I complexed with bicarbonate."J. Mol. Biol. 241:226-232(1994) [PubMed] [Europe PMC] [Abstract]
  22. "Drug-protein interactions. Refined structures of three sulfonamide drug complexes of human carbonic anhydrase I enzyme."J. Mol. Biol. 243:298-309(1994) [PubMed] [Europe PMC] [Abstract]
  23. "Crystal structure of a zinc-activated variant of human carbonic anhydrase I, CA I Michigan 1: evidence for a second zinc binding site involving arginine coordination."Biochemistry 41:6237-6244(2002) [PubMed] [Europe PMC] [Abstract]
  24. "Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I."Bioorg. Med. Chem. Lett. 16:5152-5156(2006) [PubMed] [Europe PMC] [Abstract]
  25. "Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with 'two-prong' inhibitors reveal the molecular basis of high affinity."J. Am. Chem. Soc. 128:3011-3018(2006) [PubMed] [Europe PMC] [Abstract]
  26. "Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I."Bioorg. Med. Chem. Lett. 17:2210-2215(2007) [PubMed] [Europe PMC] [Abstract]
  27. "Structural analysis of charge discrimination in the binding of inhibitors to human carbonic anhydrases I and II."J. Am. Chem. Soc. 129:5528-5537(2007) [PubMed] [Europe PMC] [Abstract]
  28. "Population genetic studies of the Philippine Negritos. III. Identification of the carbonic anhydrase-1 variant with CA1 Guam."Am. J. Hum. Genet. 33:105-111(1981) [PubMed] [Europe PMC] [Abstract]
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