Amyloid Beta Peptide 1-40 (Ab1-40)

Amyloid beta-protein (Aβ) is a peptide composed of 40 to 42 (43) amino acids, and is said to be cleaved out of the precursor protein APP (a protein composed of 695, 751, or 770 amino acids) by the action of β- or γ-secretase.

Abeta1-40 stimulated microglial cells and macrophages primed by interferon-gamma in a dose-dependent manner. Co-administration of Abeta1-40 with LPS or Pam3Cys led to an additive release of nitric oxide (NO) and tumour necrosis factor alpha (TNF-alpha). This may be one reason for the clinical deterioration frequently observed in patients with Alzheimer's disease during infections. In contrast, co-application of Abeta1-40 with CpG led to a substantial decrease of NO and TNF-alpha release compared with stimulation with CpG alone. Abeta1-40 and CpG did not co-localize within the same subcellular compartment, making a direct physicochemical interaction as the cause of the observed antagonism very unlikely.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins CPA864Hu11 BSA Conjugated Amyloid Beta Peptide 1-40 (Ab1-40) Immunogen; SDS-PAGE; WB.
CPA864Hu21 OVA Conjugated Amyloid Beta Peptide 1-40 (Ab1-40) Immunogen; SDS-PAGE; WB.
CPA864Hu31 KLH Conjugated Amyloid Beta Peptide 1-40 (Ab1-40) Immunogen; SDS-PAGE; WB.
CPA864Hu23 OVA Conjugated Amyloid Beta Peptide 1-40 (Ab1-40) Immunogen; SDS-PAGE; WB.
SPA864Hu02 Synthetic Amyloid Beta Peptide 1-40 (Ab1-40) Immunogen; Blocking Peptide.
CPA864Hu12 BSA Conjugated Amyloid Beta Peptide 1-40 (Ab1-40) Immunogen; SDS-PAGE; WB.
CPA864Hu22 OVA Conjugated Amyloid Beta Peptide 1-40 (Ab1-40) Immunogen; SDS-PAGE; WB.
RPA864Hu01 Recombinant Amyloid Beta Peptide 1-40 (Ab1-40) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA864Hu08 Polyclonal Antibody to Amyloid Beta Peptide 1-40 (Ab1-40) WB; IHC; ICC; IP.
PAA864Hu01 Polyclonal Antibody to Amyloid Beta Peptide 1-40 (Ab1-40) WB; IHC; ICC; IP.
Assay Kits CEA864Hu ELISA Kit for Amyloid Beta Peptide 1-40 (Ab1-40) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins CPA864Mu11 BSA Conjugated Amyloid Beta Peptide 1-40 (Ab1-40) Immunogen; SDS-PAGE; WB.
CPA864Mu21 OVA Conjugated Amyloid Beta Peptide 1-40 (Ab1-40) Immunogen; SDS-PAGE; WB.
CPA864Mu31 KLH Conjugated Amyloid Beta Peptide 1-40 (Ab1-40) Immunogen; SDS-PAGE; WB.
Antibodies PAA864Mu08 Polyclonal Antibody to Amyloid Beta Peptide 1-40 (Ab1-40) WB; IHC; ICC; IP.
Assay Kits CEA864Mu ELISA Kit for Amyloid Beta Peptide 1-40 (Ab1-40) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins CPA864Ra11 BSA Conjugated Amyloid Beta Peptide 1-40 (Ab1-40) Immunogen; SDS-PAGE; WB.
CPA864Ra21 OVA Conjugated Amyloid Beta Peptide 1-40 (Ab1-40) Immunogen; SDS-PAGE; WB.
CPA864Ra31 KLH Conjugated Amyloid Beta Peptide 1-40 (Ab1-40) Immunogen; SDS-PAGE; WB.
Antibodies PAA864Ra08 Polyclonal Antibody to Amyloid Beta Peptide 1-40 (Ab1-40) WB; IHC; ICC; IP.
Assay Kits CEA864Ra ELISA Kit for Amyloid Beta Peptide 1-40 (Ab1-40) Enzyme-linked immunosorbent assay for Antigen Detection.