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Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4)

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CD252; TXGP1; OX40L; Gp34; OX40-L; Tax-Transcriptionally Activated Glycoprotein 1,34kD; Glycoprotein Gp34; OX40 ligand

Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4)
CCC A850
HGNC 11934
MGI 104511
PubMed 23874208
RGD 619816
UniProt P23510
Wiki TNFSF4

OX40L(TNFSF4;CD252) is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells.

This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells. The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA850Hu01 Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA850Hu01 Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4) WB; IHC; ICC; IP.
MAA850Hu22 Monoclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4) WB; IHC; ICC; IP.
Assay Kits SEA850Hu ELISA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins EPA850Mu61 Eukaryotic Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4) Positive Control; Immunogen; SDS-PAGE; WB.
APA850Mu61 Active Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4) Cell culture; Activity Assays.
EPA850Mu62 Eukaryotic Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 4 (TNFSF4) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax."Mol. Cell. Biol. 11:1313-1325(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor."J. Exp. Med. 180:757-762(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "New variations in human OX40 ligand (CD134L) gene."Genes Immun. 1:521-522(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34."EMBO J. 13:3992-4001(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus."Nat. Genet. 40:83-89(2008) [PubMed] [Europe PMC] [Abstract]
  9. "The crystal structure of the costimulatory OX40-OX40L complex."Structure 14:1321-1330(2006) [PubMed] [Europe PMC] [Abstract]