Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14)

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CD258; TR2; HVEML; LIGHT; LTg; Herpes virus entry mediator ligand; Herpesvirus entry mediator ligand

Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14)

Tumor necrosis factor ligand superfamily member 14 is a protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA827Hu01 Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA827Hu01 Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) WB; IHC
LAA827Hu71 Biotin-Linked Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) WB; IHC; ICC.
MAA827Hu21 Monoclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) WB
LAA827Hu72 Biotin-Linked Monoclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) WB; IHC; ICC.
Assay Kits SEA827Hu ELISA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA827Mu01 Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) Positive Control; Immunogen; SDS-PAGE; WB.
RPA827Mu02 Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA827Mu01 Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) WB; IHC; ICC; IP.
LAA827Mu71 Biotin-Linked Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) WB; IHC; ICC.
LAA827Mu81 FITC-Linked Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) WB; IHC; ICC; IF.
PAA827Mu02 Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) WB; IHC; ICC; IP.
Assay Kits SEA827Mu ELISA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA827Ra01 Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA827Ra01 Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) WB; IHC
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) ELISA Kit Customized Service Offer
  1. "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator."Immunity 8:21-30(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth."J. Biol. Chem. 273:27548-27556(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis."J. Immunol. 167:5122-5128(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of LIGHT."Submitted (MAY-2012) to the PDB data bank