Cluster Of Differentiation 86 (CD86)

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LAB7-2; B7-2; B70; FUN-1; CD28LG2; CD28 Antigen Ligand 2,B7-2 Antigen; CTLA-4 counter-receptor B7.2; B-Lymphocyte Activation Antigen B7-2

Cluster Of Differentiation 86 (CD86)

The protein CD86 is a molecule expressed on antigen-presenting cells that provide costimulatory signals necessary for T cell activation and survival. It is the ligand for two proteins at the cell surface of T cells, CD28 antigen and CTLA-4 (cytotoxic T-lymphocyte-associated protein 4). CD86 is also known as B7.2. Its principal mode of action is by binding to CD28. Along with CD80, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with CTLA-4 negatively regulates T-cell activation and diminishes the immune response.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA824Hu01 Recombinant Cluster Of Differentiation 86 (CD86) Positive Control; Immunogen; SDS-PAGE; WB.
EPA824Hu61 Eukaryotic Cluster Of Differentiation 86 (CD86) Positive Control; Immunogen; SDS-PAGE; WB.
APA824Hu61 Active Cluster Of Differentiation 86 (CD86) Cell culture; Activity Assays.
Antibodies PAA824Hu01 Polyclonal Antibody to Cluster Of Differentiation 86 (CD86) WB; IHC; ICC; IP.
MAA824Hu22 Monoclonal Antibody to Cluster Of Differentiation 86 (CD86) WB; IHC; ICC; IP.
MAA824Hu21 Monoclonal Antibody to Cluster Of Differentiation 86 (CD86) WB; IHC; ICC; IP.
Assay Kits SEA824Hu ELISA Kit for Cluster Of Differentiation 86 (CD86) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA824Mu01 Recombinant Cluster Of Differentiation 86 (CD86) Positive Control; Immunogen; SDS-PAGE; WB.
RPA824Mu02 Recombinant Cluster Of Differentiation 86 (CD86) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA824Mu01 Polyclonal Antibody to Cluster Of Differentiation 86 (CD86) WB; IHC; ICC; IP.
Assay Kits SEA824Mu ELISA Kit for Cluster Of Differentiation 86 (CD86) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster Of Differentiation 86 (CD86) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 86 (CD86) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 86 (CD86) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 86 (CD86) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 86 (CD86) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster Of Differentiation 86 (CD86) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 86 (CD86) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 86 (CD86) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 86 (CD86) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 86 (CD86) ELISA Kit Customized Service Offer
  1. "B70 antigen is a second ligand for CTLA-4 and CD28."Nature 366:76-79(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation."Science 262:909-911(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of an alternatively spliced variant of human CD86 mRNA."Biochem. Biophys. Res. Commun. 280:1211-1215(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86)."Immunogenetics 42:85-89(1995) [PubMed] [Europe PMC] [Abstract]
  8. "CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL."J. Immunol. 154:97-105(1995) [PubMed] [Europe PMC] [Abstract]
  9. "The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen."Blood 84:1402-1407(1994) [PubMed] [Europe PMC] [Abstract]
  10. "c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity."J. Biol. Chem. 278:14657-14668(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors."Virus Res. 122:144-153(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Structural basis for co-stimulation by the human CTLA-4/B7-2 complex."Nature 410:604-608(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling."Proc. Natl. Acad. Sci. U.S.A. 100:2586-2591(2003) [PubMed] [Europe PMC] [Abstract]