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Amylin

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IAPP; IAP; DAP; Islet Amyloid Polypeptide; Insulinoma Amyloid Polypeptide; Diabetes-associated peptide

Amylin
CCC A812
HGNC 5329
MGI 96382
PubMed 19475663
RGD 2854
UniProt P10997
Wiki IAPP

Islet, or insulinoma, amyloid polypeptide (IAPP, or amylin) is commonly found in pancreatic islets of patients suffering diabetes mellitus type 2, or harboring an insulinoma. While the association of amylin with the development of type 2 diabetes has been known for some time, a direct causative role for amylin has been harder to establish.

Recent results suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in insulin-producing beta cells, an effect that may be relevant to the development of type 2 diabetes. Finally, a recent study reported a synergistic effect for weight loss with leptin and amylin coadministration in diet-induced obese rats by restoring hypothalamic sensitivity to leptin .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA812Hu01 Recombinant Amylin Positive Control; Immunogen; SDS-PAGE; WB.
CPA812Hu22 OVA Conjugated Amylin Immunogen; SDS-PAGE; WB.
CPA812Hu11 BSA Conjugated Amylin Immunogen; SDS-PAGE; WB.
CPA812Hu21 OVA Conjugated Amylin Immunogen; SDS-PAGE; WB.
CPA812Hu33 KLH Conjugated Amylin Immunogen; SDS-PAGE; WB.
Antibodies PAA812Hu01 Polyclonal Antibody to Amylin WB; IHC; ICC; IP.
MAA812Hu22 Monoclonal Antibody to Amylin WB,IHC
PAA812Hu07 Polyclonal Antibody to Amylin WB; IHC; ICC; IP.
PAA812Hu08 Polyclonal Antibody to Amylin WB; IHC; ICC; IP.
MAA812Mi28 Monoclonal Antibody to Amylin WB; IHC; ICC; IP.
Assay Kits CEA812Hu ELISA Kit for Amylin Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA812Mu01 Recombinant Amylin Positive Control; Immunogen; SDS-PAGE; WB.
RPA812Mu02 Recombinant Amylin Positive Control; Immunogen; SDS-PAGE; WB.
CPA812Mu11 BSA Conjugated Amylin Immunogen; SDS-PAGE; WB.
CPA812Mu21 OVA Conjugated Amylin Immunogen; SDS-PAGE; WB.
Antibodies PAA812Mu01 Polyclonal Antibody to Amylin WB; IHC; ICC; IP.
PAA812Mu02 Polyclonal Antibody to Amylin WB; IHC; ICC; IP.
PAA812Mu08 Polyclonal Antibody to Amylin WB; IHC; ICC; IP.
Assay Kits CEA812Mu ELISA Kit for Amylin Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA812Ra01 Recombinant Amylin Positive Control; Immunogen; SDS-PAGE; WB.
CPA812Ra11 BSA Conjugated Amylin Immunogen; SDS-PAGE; WB.
CPA812Ra21 OVA Conjugated Amylin Immunogen; SDS-PAGE; WB.
Antibodies PAA812Ra01 Polyclonal Antibody to Amylin WB; IHC; ICC; IP.
MAA812Ra21 Monoclonal Antibody to Amylin WB; IHC; ICC; IP.
PAA812Ra08 Polyclonal Antibody to Amylin WB; IHC; ICC; IP.
Assay Kits CEA812Ra ELISA Kit for Amylin Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amylin Recombinant Protein Customized Service Offer
Antibodies MAA812Ge21 Monoclonal Antibody to Amylin WB; IHC; ICC; IP.
MAA812Ge28 Monoclonal Antibody to Amylin WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Amylin CLIA Kit Customized Service Offer
n/a ELISA Kit for Amylin ELISA Kit Customized Service Offer
  1. "The complete islet amyloid polypeptide precursor is encoded by two exons."FEBS Lett. 247:154-158(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Human islet amyloid polypeptide gene: complete nucleotide sequence, chromosomal localization, and evolutionary history."Mol. Endocrinol. 3:1775-1781(1989) [PubMed] [Europe PMC] [Abstract]
  3. "An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing."J. Biol. Chem. 263:17243-17246(1988) [PubMed] [Europe PMC] [Abstract]
  4. "The human islet amyloid polypeptide (IAPP) gene. Organization, chromosomal localization and functional identification of a promoter region."FEBS Lett. 267:160-166(1990) [PubMed] [Europe PMC] [Abstract]
  5. "Islet amyloid polypeptide: structure and upstream sequences of the IAPP gene in rat and man."Biochim. Biophys. Acta 1087:235-240(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of the human islet amyloid polypeptide/amylin gene transcripts: identification of a new polyadenylation site."Biochem. Biophys. Res. Commun. 189:1569-1577(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning and expression of human islet amyloid polypeptide in cultured cells."Biochem. Biophys. Res. Commun. 356:622-628(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Islet amyloid polypeptide: identification and chromosomal localization of the human gene."FEBS Lett. 239:227-232(1988) [PubMed] [Europe PMC] [Abstract]
  9. "Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients."Proc. Natl. Acad. Sci. U.S.A. 84:8628-8632(1987) [PubMed] [Europe PMC] [Abstract]
  10. "Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species."FEBS Lett. 251:261-264(1989) [PubMed] [Europe PMC] [Abstract]
  11. "Isolation and identification of islet amyloid polypeptide in normal human pancreas."Regul. Pept. 31:179-186(1990) [PubMed] [Europe PMC] [Abstract]
  12. "A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas."Biochem. Biophys. Res. Commun. 140:827-831(1986) [PubMed] [Europe PMC] [Abstract]
  13. "Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells."Proc. Natl. Acad. Sci. U.S.A. 84:3881-3885(1987) [PubMed] [Europe PMC] [Abstract]
  14. "Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus."Proc. Natl. Acad. Sci. U.S.A. 86:9662-9666(1989) [PubMed] [Europe PMC] [Abstract]
  15. "Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin."Biochem. J. 275:785-788(1991) [PubMed] [Europe PMC] [Abstract]
  16. "Conformational preferences of the amylin nucleation site in SDS micelles: an NMR study."Biopolymers 69:29-41(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism."Nature 443:870-874(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Dynamic alpha-helix structure of micelle-bound human amylin."J. Biol. Chem. 284:11982-11991(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process."Protein Sci. 18:1521-1530(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Missense mutation of amylin gene (S20G) in Japanese NIDDM patients."Diabetes 45:1279-1281(1996) [PubMed] [Europe PMC] [Abstract]
  21. "Role of S20G mutation of amylin gene in insulin secretion, insulin sensitivity, and type II diabetes mellitus in Taiwanese patients."Diabetologia 41:1250-1251(1998) [PubMed] [Europe PMC] [Abstract]