Pregnancy Associated Plasma Protein A (PAPPA)

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PAPP-A; PAPA; ASBABP2; DIPLA1; IGFBP-4ase; PAPPA1; Pappalysin 1; Insulin-Like Growth Factor Binding Protein-4 Protease; Differentially Placenta 1 Expressed Protein

Pregnancy Associated Plasma Protein A (PAPPA)
  • PAPP-A is a large heterottetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down’s syndrome. a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses (fetuses with an abnormal number of chromosomes). For example, low PAPPA may be seen in prenatal screening for Down syndrome.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA800Hu01 Recombinant Pregnancy Associated Plasma Protein A (PAPPA) Positive Control; Immunogen; SDS-PAGE; WB.
RPA800Hu02 Recombinant Pregnancy Associated Plasma Protein A (PAPPA) Positive Control; Immunogen; SDS-PAGE; WB.
RPA800Hu03 Recombinant Pregnancy Associated Plasma Protein A (PAPPA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA800Hu01 Polyclonal Antibody to Pregnancy Associated Plasma Protein A (PAPPA) WB; IHC; ICC; IP.
MAA800Hu22 Monoclonal Antibody to Pregnancy Associated Plasma Protein A (PAPPA) WB; IHC; ICC; IP.
PAA800Hu02 Polyclonal Antibody to Pregnancy Associated Plasma Protein A (PAPPA) WB; IHC; ICC; IP.
PAA800Hu03 Polyclonal Antibody to Pregnancy Associated Plasma Protein A (PAPPA) WB; IHC; ICC; IP.
LAA800Hu71 Biotin-Linked Polyclonal Antibody to Pregnancy Associated Plasma Protein A (PAPPA) WB; IHC; ICC.
Assay Kits SEA800Hu ELISA Kit for Pregnancy Associated Plasma Protein A (PAPPA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA800Mu01 Recombinant Pregnancy Associated Plasma Protein A (PAPPA) Positive Control; Immunogen; SDS-PAGE; WB.
RPA800Mu02 Recombinant Pregnancy Associated Plasma Protein A (PAPPA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA800Mu01 Polyclonal Antibody to Pregnancy Associated Plasma Protein A (PAPPA) WB; IHC; ICC; IP.
LAA800Mu81 FITC-Linked Polyclonal Antibody to Pregnancy Associated Plasma Protein A (PAPPA) WB; IHC; ICC; IF.
LAA800Mu71 Biotin-Linked Polyclonal Antibody to Pregnancy Associated Plasma Protein A (PAPPA) WB; IHC; ICC.
PAA800Mu02 Polyclonal Antibody to Pregnancy Associated Plasma Protein A (PAPPA) WB; IHC; ICC; IP.
Assay Kits SEA800Mu ELISA Kit for Pregnancy Associated Plasma Protein A (PAPPA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pregnancy Associated Plasma Protein A (PAPPA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pregnancy Associated Plasma Protein A (PAPPA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pregnancy Associated Plasma Protein A (PAPPA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pregnancy Associated Plasma Protein A (PAPPA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pregnancy Associated Plasma Protein A (PAPPA) ELISA Kit Customized Service Offer
  1. "Complete cDNA sequence of the preproform of human pregnancy-associated plasma protein-A. Evidence for expression in the brain and induction by cAMP."Eur. J. Biochem. 237:159-163(1996) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA."Biochemistry 33:1592-1598(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein."J. Biol. Chem. 268:12243-12246(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment sites."J. Biol. Chem. 278:2106-2117(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A."Proc. Natl. Acad. Sci. U.S.A. 96:3149-3153(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor."J. Biol. Chem. 275:31128-31133(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta."Lab. Invest. 71:560-566(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues."Biol. Reprod. 61:1083-1089(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma."J. Biol. Chem. 270:13645-13651(1995) [PubMed] [Europe PMC] [Abstract]
  12. "Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A."FEBS Lett. 504:36-40(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene."Am. J. Hum. Genet. 70:663-672(2002) [PubMed] [Europe PMC] [Abstract]