Bone Morphogenetic Protein 7 (BMP7)

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OP1; Osteogenic Protein-1; Eptotermin alfa

Bone Morphogenetic Protein 7 (BMP7)

The protein encoded by this gene is a member of the TGF-β superfamily. Like other members of the bone morphogenetic protein family of proteins, it plays a key role in the transformation of mesenchymal cells into bone and cartilage. It is inhibited by noggin and a similar protein, chordin, which are expressed in the Spemann-Mangold Organizer. BMP7 may be involved in bone homeostasis. It is expressed in the brain, kidneys and bladder.

BMP7 has been discovered to be crucial in the determination of ventral-dorsal organization in zebrafish. BMP7 causes the expression of ventral phenotypes while its complete inhibition creates a dorsal phenotype. Moreover, BMP7 is eventually partially "turned off" in embryonic development in order to create the dorsal parts of the organism.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA799Hu01 Recombinant Bone Morphogenetic Protein 7 (BMP7) Positive Control; Immunogen; SDS-PAGE; WB.
RPA799Hu02 Recombinant Bone Morphogenetic Protein 7 (BMP7) Positive Control; Immunogen; SDS-PAGE; WB.
APA799Hu01 Active Bone Morphogenetic Protein 7 (BMP7) Cell culture; Activity Assays.
Antibodies PAA799Hu01 Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB; IHC; ICC; IP.
MAA799Hu22 Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB
PAA799Hu02 Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB; IHC; ICC; IP.
LAA799Hu72 Biotin-Linked Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB; IHC; ICC.
MAA799Hu21 Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB; IHC; ICC; IP.
MAA799Hu24 Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB; IHC; ICC; IP.
MAA799Hu23 Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB; IHC; ICC; IP.
MAA799Hu25 Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB; IHC; ICC; IP.
MAA799Hu27 Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB; IHC; ICC; IP.
Assay Kits SEA799Hu ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA799Mu01 Recombinant Bone Morphogenetic Protein 7 (BMP7) Positive Control; Immunogen; SDS-PAGE; WB.
RPA799Mu02 Recombinant Bone Morphogenetic Protein 7 (BMP7) Positive Control; Immunogen; SDS-PAGE; WB.
APA799Mu01 Active Bone Morphogenetic Protein 7 (BMP7) Cell culture; Activity Assays.
Antibodies PAA799Mu01 Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB; IHC; ICC; IP.
LAA799Mu71 Biotin-Linked Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB; IHC; ICC.
PAA799Mu02 Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB; IHC; ICC; IP.
MAA799Mu21 Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB; IHC; ICC; IP.
LAA799Mu72 Biotin-Linked Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB; IHC; ICC.
Assay Kits SEA799Mu ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA799Ra01 Recombinant Bone Morphogenetic Protein 7 (BMP7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA799Ra01 Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB; IHC; ICC; IP.
MAA799Ra21 Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB; IHC; ICC; IP.
LAA799Ra72 Biotin-Linked Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB; IHC; ICC.
Assay Kits SEA799Ra ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA799Rb01 Recombinant Bone Morphogenetic Protein 7 (BMP7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bone Morphogenetic Protein 7 (BMP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA799Bo01 Recombinant Bone Morphogenetic Protein 7 (BMP7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA799Bo01 Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Bone Morphogenetic Protein 7 (BMP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) ELISA Kit Customized Service Offer

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bone Morphogenetic Protein 7 (BMP7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) Polyclonal Antibody Customized Service Offer
Assay Kits SEA799Ov ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "OP-1 cDNA encodes an osteogenic protein in the TGF-beta family."EMBO J. 9:2085-2093(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone."Proc. Natl. Acad. Sci. U.S.A. 87:9843-9847(1990) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Expression and characterization of a human BMP-7 variant with improved biochemical properties."Protein Expr. Purif. 57:312-319(2008) [PubMed] [Europe PMC] [Abstract]
  6. "USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney."Biochem. Biophys. Res. Commun. 316:490-500(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomalies."Hum. Mutat. 31:781-787(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily."Proc. Natl. Acad. Sci. U.S.A. 93:878-883(1996) [PubMed] [Europe PMC] [Abstract]