Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17)

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CD269; BCM; BCMA; B-cell maturation protein

Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17)

Tumor necrosis factor receptor superfamily member 17 is  a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b, and to lead to NF-kappaB and MAPK8/JNK activation.

This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.The patient from whose tumor cells the 4;16 translocation was derived had a chronic intestinal malabsorption syndrome. Histologic and immunohistochemical studies demonstrated a lymphoproliferative syndrome of mature T cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins APA790Hu01 Active Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Cell culture; Activity Assays.
RPA790Hu01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA790Mu01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Positive Control; Immunogen; SDS-PAGE; WB.
RPA790Mu02 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA790Mu01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IP.
LAA790Mu71 Biotin-Linked Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC.
PAA790Mu02 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IP.
Assay Kits SEA790Mu ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) ELISA Kit Customized Service Offer
  1. "A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma."EMBO J. 11:3897-3904(1992) [PubMed] [Europe PMC] [Abstract]
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  9. "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity."Nat. Immunol. 1:252-256(2000) [PubMed] [Europe PMC] [Abstract]
  10. "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1."Proc. Natl. Acad. Sci. U.S.A. 97:9156-9161(2000) [PubMed] [Europe PMC] [Abstract]
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  12. "Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding."J. Biol. Chem. 280:7218-7227(2005) [PubMed] [Europe PMC] [Abstract]