Lactoferrin (LTF)

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HLF2; LF; GIG12; Lactotransferrin; Growth-inhibiting protein 12; Talalactoferrin; Lfcin-H; Kaliocin-1

Lactoferrin (LTF)

LTF, a globular multifunctional protein with antimicrobial activity (bacteriocide, fungicide), is part of the innate defense, mainly at mucoses. Lactoferrin is found in milk and many mucosal secretions such as tears and saliva. Lactoferrin is also present in secondary granules of PMN and also is secreted by some acinar cells. Human colostrum has the highest concentration, followed by human milk, then cow milk.

Lactoferrin belongs to the transferrin family proteins (TF, melanotransferrin, ovotransferin, etc.). Its molecular mass is 80,000 u (80 kDa).Lactoferrin antimicrobial activity is due partly to its high affinity for Fe (ferric state). LF proteolysis produces lactoferricin, kaliocin-1 small peptides with antimicrobial activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA780Hu01 Recombinant Lactoferrin (LTF) Positive Control; Immunogen; SDS-PAGE; WB.
RPA780Hu02 Recombinant Lactoferrin (LTF) Positive Control; Immunogen; SDS-PAGE; WB.
NPA780Hu01 Native Lactoferrin (LTF) Positive Control; Immunogen; SDS-PAGE; WB.
APA780Hu01 Active Lactoferrin (LTF) Cell culture; Activity Assays.
Antibodies PAA780Hu01 Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
MAA780Hu22 Monoclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
PAA780Hu02 Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
LAA780Hu71 Biotin-Linked Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC.
LAA780Hu81 FITC-Linked Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IF.
LAA780Hu72 Biotin-Linked Monoclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC.
LAA780Hu82 FITC-Linked Monoclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IF.
PAA780Hu05 Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
Assay Kits SEA780Hu ELISA Kit for Lactoferrin (LTF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA780Hu CLIA Kit for Lactoferrin (LTF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA780Mu01 Recombinant Lactoferrin (LTF) Positive Control; Immunogen; SDS-PAGE; WB.
RPA780Mu02 Recombinant Lactoferrin (LTF) Positive Control; Immunogen; SDS-PAGE; WB.
RPA780Mu03 Recombinant Lactoferrin (LTF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA780Mu01 Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
PAA780Mu02 Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
PAA780Mu03 Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
LAA780Mu81 FITC-Linked Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IF.
LAA780Mu71 Biotin-Linked Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC.
Assay Kits SEA780Mu ELISA Kit for Lactoferrin (LTF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA780Ra01 Recombinant Lactoferrin (LTF) Positive Control; Immunogen; SDS-PAGE; WB.
RPA780Ra02 Recombinant Lactoferrin (LTF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA780Ra01 Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
PAA780Ra02 Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
LAA780Ra71 Biotin-Linked Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC.
Assay Kits SEA780Ra ELISA Kit for Lactoferrin (LTF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA780Ca01 Recombinant Lactoferrin (LTF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA780Ca01 Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
LAA780Ca71 Biotin-Linked Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC.
LAA780Ca81 FITC-Linked Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IF.
MAA780Ca21 Monoclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
Assay Kits SEA780Ca ELISA Kit for Lactoferrin (LTF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA780Po01 Recombinant Lactoferrin (LTF) Positive Control; Immunogen; SDS-PAGE; WB.
APA780Po01 Active Lactoferrin (LTF) Cell culture; Activity Assays.
Antibodies PAA780Po01 Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
LAA780Po81 FITC-Linked Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IF.
LAA780Po71 Biotin-Linked Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC.
MAA780Po21 Monoclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
Assay Kits SEA780Po ELISA Kit for Lactoferrin (LTF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA780Bo01 Recombinant Lactoferrin (LTF) Positive Control; Immunogen; SDS-PAGE; WB.
NPA780Bo01 Native Lactoferrin (LTF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA780Bo01 Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
MAA780Bo21 Monoclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
PAA780Bo05 Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
Assay Kits SEA780Bo ELISA Kit for Lactoferrin (LTF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA780Bo CLIA Kit for Lactoferrin (LTF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA780Cp01 Recombinant Lactoferrin (LTF) Positive Control; Immunogen; SDS-PAGE; WB.
APA780Cp01 Active Lactoferrin (LTF) Cell culture; Activity Assays.
Antibodies PAA780Cp01 Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
LAA780Cp71 Biotin-Linked Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Lactoferrin (LTF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lactoferrin (LTF) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lactoferrin (LTF) Recombinant Protein Customized Service Offer
Antibodies PAA780Eq01 Polyclonal Antibody to Lactoferrin (LTF) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Lactoferrin (LTF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lactoferrin (LTF) ELISA Kit Customized Service Offer
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  26. "Expression of lactoferrin in the kidney: implications for innate immunity and iron metabolism."Kidney Int. 57:2004-2010(2000) [PubMed] [Europe PMC] [Abstract]
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  29. "An intronic alternative promoter of the human lactoferrin gene is activated by Ets."Biochem. Biophys. Res. Commun. 301:472-479(2003) [PubMed] [Europe PMC] [Abstract]
  30. "Potassium efflux induced by a new lactoferrin-derived peptide mimicking the effect of native human lactoferrin on the bacterial cytoplasmic membrane."Biochemistry (Mosc.) 68:217-227(2003) [PubMed] [Europe PMC] [Abstract]
  31. "Human milk lactoferrin is a serine protease that cleaves Haemophilus surface proteins at arginine-rich sites."Mol. Microbiol. 47:607-617(2003) [PubMed] [Europe PMC] [Abstract]
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  41. "Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling."FEBS J. 277:2051-2066(2010) [PubMed] [Europe PMC] [Abstract]
  42. "O-GlcNAcylation/phosphorylation cycling at Ser10 controls both transcriptional activity and stability of delta-lactoferrin."J. Biol. Chem. 285:19205-19218(2010) [PubMed] [Europe PMC] [Abstract]
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  62. "'Dilysine trigger' in transferrins probed by mutagenesis of lactoferrin: crystal structures of the R210G, R210E, and R210L mutants of human lactoferrin."Biochemistry 41:14167-14175(2002) [PubMed] [Europe PMC] [Abstract]
  63. "Structure of human diferric lactoferrin at 2.5A resolution using crystals grown at pH 6.5."Submitted (MAR-2004) to the PDB data bank
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  66. "Crystal structure of the complex formed between proteinase K and a human lactoferrin fragment at 2.9 A resolution."Submitted (MAY-2006) to the PDB data bank
  67. "Crystal structure of proteinase K inhibited by a lactoferrin octapeptide Gly-Asp-Glu-Gln-Gly-Glu-Asn-Lys at 2.15 A resolution."Submitted (JUN-2006) to the PDB data bank
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