Glucocorticoid Receptor Beta (GRb)

Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans.Alternative splicing of the human glucocorticoid receptor (hGR) pre-mRNA generates two highly homologous isoforms, termed hGR alpha and hGR beta. hGR alpha is a ligand-activated transcription factor which, in the hormone-bound state, modulates the expression of glucocorticoid-responsive genes by binding to specific glucocorticoid response element (GRE) DNA sequences. In contrast, hGR beta does not bind glucocorticoids and is transcriptionally inactive. These results indicate that hGR beta may be a physiologically and pathophysiologically relevant endogenous inhibitor of glucocorticoid action, which may participate in defining the sensitivity of target tissues to glucocorticoids. They also underline the importance of distinguishing between the two receptor isoforms in all future studies of hGR function and the need to revisit old data.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA773Hu01 Recombinant Glucocorticoid Receptor Beta (GRb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Glucocorticoid Receptor Beta (GRb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glucocorticoid Receptor Beta (GRb) Polyclonal Antibody Customized Service Offer
Assay Kits SEA773Hu ELISA Kit for Glucocorticoid Receptor Beta (GRb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Glucocorticoid Receptor Beta (GRb) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glucocorticoid Receptor Beta (GRb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glucocorticoid Receptor Beta (GRb) Polyclonal Antibody Customized Service Offer
Assay Kits SEA773Mu ELISA Kit for Glucocorticoid Receptor Beta (GRb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Glucocorticoid Receptor Beta (GRb) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glucocorticoid Receptor Beta (GRb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glucocorticoid Receptor Beta (GRb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glucocorticoid Receptor Beta (GRb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucocorticoid Receptor Beta (GRb) ELISA Kit Customized Service Offer