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A Disintegrin And Metalloprotease 10 (ADAM10)

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CD156-C; CD156c; MADM; Kuz; CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease

A Disintegrin And Metalloprotease 10 (ADAM10)
CCC A766
HGNC 188
MGI 109548
PubMed 21205794
RGD 2032
UniProt O14672
Wiki ADAM10

A Disintegrin And Metalloprotease 10 is a ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. ADAM10 is a sheddase, and has a broad specificity for peptide hydrolysis reactions. New data on the ADAM10 shedding of ephrin/eph complex associated with Eph on one cell surface has determined that ADAM10 cleaves ephrin, within the ephrin/eph complex, formed between two cell surfaces. When ephrin is freed from the opposing cell, the entire ephrin/eph complex is endocytosed. This shedding in trans had not been previously shown, but may well be involved in other shedding events.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA766Hu01 Recombinant A Disintegrin And Metalloprotease 10 (ADAM10) Positive Control; Immunogen; SDS-PAGE; WB.
EPA766Hu61 Eukaryotic A Disintegrin And Metalloprotease 10 (ADAM10) Positive Control; Immunogen; SDS-PAGE; WB.
EPA766Hu62 Eukaryotic A Disintegrin And Metalloprotease 10 (ADAM10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA766Hu01 Polyclonal Antibody to A Disintegrin And Metalloprotease 10 (ADAM10) WB; IHC; ICC; IP.
MAA766Hu22 Monoclonal Antibody to A Disintegrin And Metalloprotease 10 (ADAM10) WB; IHC; ICC; IP.
LAA766Hu71 Biotin-Linked Polyclonal Antibody to A Disintegrin And Metalloprotease 10 (ADAM10) WB; IHC; ICC.
Assay Kits SEA766Hu ELISA Kit for A Disintegrin And Metalloprotease 10 (ADAM10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA766Mu01 Recombinant A Disintegrin And Metalloprotease 10 (ADAM10) Positive Control; Immunogen; SDS-PAGE; WB.
RPA766Mu02 Recombinant A Disintegrin And Metalloprotease 10 (ADAM10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA766Mu01 Polyclonal Antibody to A Disintegrin And Metalloprotease 10 (ADAM10) WB; IHC; ICC; IP.
PAA766Mu02 Polyclonal Antibody to A Disintegrin And Metalloprotease 10 (ADAM10) WB; IHC; ICC; IP.
Assay Kits SEA766Mu ELISA Kit for A Disintegrin And Metalloprotease 10 (ADAM10) Enzyme-linked immunosorbent assay for Antigen Detection.
HEA766Mu High Sensitive ELISA Kit for A Disintegrin And Metalloprotease 10 (ADAM10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA766Ra01 Recombinant A Disintegrin And Metalloprotease 10 (ADAM10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA766Ra01 Polyclonal Antibody to A Disintegrin And Metalloprotease 10 (ADAM10) WB; IHC; ICC; IP.
MAA766Ra21 Monoclonal Antibody to A Disintegrin And Metalloprotease 10 (ADAM10) WB; IHC; ICC; IP.
Assay Kits SEA766Ra ELISA Kit for A Disintegrin And Metalloprotease 10 (ADAM10) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA766Ra CLIA Kit for A Disintegrin And Metalloprotease 10 (ADAM10) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Disintegrin And Metalloprotease 10 (ADAM10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Disintegrin And Metalloprotease 10 (ADAM10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Disintegrin And Metalloprotease 10 (ADAM10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Disintegrin And Metalloprotease 10 (ADAM10) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Disintegrin And Metalloprotease 10 (ADAM10) ELISA Kit Customized Service Offer
  1. "Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases."J. Biol. Chem. 272:24588-24593(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types."Biochem. J. 317:45-50(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes."Biochem. Biophys. Res. Commun. 230:335-339(1997) [PubMed] [Europe PMC] [Abstract]
  6. "ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles."FASEB J. 17:292-294(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein."J. Biol. Chem. 276:37743-37746(2001) [PubMed] [Europe PMC] [Abstract]
  8. "ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage."J. Histochem. Cytochem. 49:1165-1176(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells."Nat. Med. 8:41-46(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans."Cell 123:291-304(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
  12. "The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells."Cell Death Differ. 14:1678-1687(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis."J. Biol. Chem. 284:5662-5670(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI."J. Biol. Chem. 285:11793-11799(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Junctional adhesion molecule-C is a soluble mediator of angiogenesis."J. Immunol. 185:1777-1785(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Ectodomain shedding and autocleavage of the cardiac membrane protease corin."J. Biol. Chem. 286:10066-10072(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity."Hum. Mol. Genet. 18:3987-3996(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."Hum. Mutat. 32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Whole-exome sequencing identifies ADAM10 mutations as a cause of reticulate acropigmentation of Kitamura, a clinical entity distinct from Dowling-Degos disease."Hum. Mol. Genet. 22:3524-3533(2013) [PubMed] [Europe PMC] [Abstract]
  24. "ADAM10 missense mutations potentiate beta-amyloid accumulation by impairing prodomain chaperone function."Neuron 80:385-401(2013) [PubMed] [Europe PMC] [Abstract]