Forkhead Box Protein P1 (FOXP1)

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FOX-P1; 12CC4; QRF1; HFKH1B; Fork Head-Related Protein Like B; Glutamine-Rich Factor 1; PAX5/FOXP1 Fusion Protein

Forkhead Box Protein P1 (FOXP1)

FOXP1 ("forkhead box P1") is a gene that is necessary for the proper development of the brain and lung in mammals. It is a member of the large FOX family of transcription factors.

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family.Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA765Hu01 Recombinant Forkhead Box Protein P1 (FOXP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA765Hu01 Polyclonal Antibody to Forkhead Box Protein P1 (FOXP1) WB; IHC; ICC; IP.
Assay Kits SEA765Hu ELISA Kit for Forkhead Box Protein P1 (FOXP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA765Mu01 Recombinant Forkhead Box Protein P1 (FOXP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA765Mu01 Polyclonal Antibody to Forkhead Box Protein P1 (FOXP1) WB; IHC; ICC; IP.
Assay Kits SEA765Mu ELISA Kit for Forkhead Box Protein P1 (FOXP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Forkhead Box Protein P1 (FOXP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Forkhead Box Protein P1 (FOXP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Forkhead Box Protein P1 (FOXP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Forkhead Box Protein P1 (FOXP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein P1 (FOXP1) ELISA Kit Customized Service Offer
  1. "The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p."Cancer Res. 61:8820-8829(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia."Nature 446:758-764(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1."J. Clin. Invest. 114:408-418(2004) [PubMed] [Europe PMC] [Abstract]
  8. "FOXP1 is an androgen-responsive transcription factor that negatively regulates androgen receptor signaling in prostate cancer cells."Biochem. Biophys. Res. Commun. 374:388-393(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function."Blood 112:4699-4711(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Cooperative regulation in development by SMRT and FOXP1."Genes Dev. 22:740-745(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  12. "De novo mutations in FOXP1 in cases with intellectual disability, autism, and language impairment."Am. J. Hum. Genet. 87:671-678(2010) [PubMed] [Europe PMC] [Abstract]
  13. "An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming."Cell 147:132-146(2011) [PubMed] [Europe PMC] [Abstract]
  14. "FoxP1 stimulates angiogenesis by repressing the inhibitory guidance protein semaphorin 5B in endothelial cells."PLoS ONE 8:E70873-E70873(2013) [PubMed] [Europe PMC] [Abstract]
  15. "FOXP1 directly represses transcription of pro-apoptotic genes and cooperates with NF-kappaB to promote survival of human B-cells."Blood 124:3431-3440(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Transcriptional Regulation by FOXP1, FOXP2, and FOXP4 Dimerization."J. Mol. Neurosci. 55:437-448(2015) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: insight into its domain swapping and DNA binding."Protein Sci. 20:908-924(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia."Eur. J. Hum. Genet. 17:1354-1358(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Identification of FOXP1 deletions in three unrelated patients with mental retardation and significant speech and language deficits." Hum. Mutat. 31:E1851-E1860(2010) [PubMed] [Europe PMC] [Abstract]