Mucin 5 Subtype AC (MUC5AC)

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TBM; MUC5; LeB; Oligomeric Mucus/Gel-Forming; Mucin 5,Subtypes A And C,Tracheobronchial/Gastric; Gastric mucin; Lewis B blood group antigen; Major airway glycoprotein

Mucin 5 Subtype AC (MUC5AC)

MUC5AC is a secreted mucin aberrantly expressed by polypoid colorectal adenomas. It has been hypothesised that the "normal" surrounding colorectal mucosa expresses MUC5AC as a field change phenomenon that can be used to predict adenoma recurrence following resection.Mucins are high molecular mass, highly glycosylated macromolecules that are the major components of mucus secretions. MUC5B is a salivary mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva. It is composed of 14.9% protein, 78.1% carbohydrate, and 7% sulfate. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA756Hu01 Recombinant Mucin 5 Subtype AC (MUC5AC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA756Hu01 Polyclonal Antibody to Mucin 5 Subtype AC (MUC5AC) WB; IHC; ICC; IP.
MAA756Hu22 Monoclonal Antibody to Mucin 5 Subtype AC (MUC5AC) WB; IHC; ICC; IP.
LAA756Hu71 Biotin-Linked Polyclonal Antibody to Mucin 5 Subtype AC (MUC5AC) WB; IHC; ICC.
LAA756Hu81 FITC-Linked Polyclonal Antibody to Mucin 5 Subtype AC (MUC5AC) WB; IHC; ICC; IF.
MAA756Hu21 Monoclonal Antibody to Mucin 5 Subtype AC (MUC5AC) WB; IHC; ICC; IP.
LAA756Hu72 Biotin-Linked Monoclonal Antibody to Mucin 5 Subtype AC (MUC5AC) WB; IHC; ICC.
Assay Kits SEA756Hu ELISA Kit for Mucin 5 Subtype AC (MUC5AC) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA756Hu CLIA Kit for Mucin 5 Subtype AC (MUC5AC) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA756Mu01 Recombinant Mucin 5 Subtype AC (MUC5AC) Positive Control; Immunogen; SDS-PAGE; WB.
RPA756Mu02 Recombinant Mucin 5 Subtype AC (MUC5AC) Positive Control; Immunogen; SDS-PAGE; WB.
RPA756Mu03 Recombinant Mucin 5 Subtype AC (MUC5AC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA756Mu01 Polyclonal Antibody to Mucin 5 Subtype AC (MUC5AC) WB; IHC; ICC; IP.
PAA756Mu02 Polyclonal Antibody to Mucin 5 Subtype AC (MUC5AC) WB; IHC; ICC; IP.
LAA756Mu81 FITC-Linked Polyclonal Antibody to Mucin 5 Subtype AC (MUC5AC) WB; IHC; ICC; IF.
LAA756Mu71 Biotin-Linked Polyclonal Antibody to Mucin 5 Subtype AC (MUC5AC) WB; IHC; ICC.
PAA756Mu03 Polyclonal Antibody to Mucin 5 Subtype AC (MUC5AC) WB; IHC; ICC; IP.
Assay Kits SEA756Mu ELISA Kit for Mucin 5 Subtype AC (MUC5AC) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA756Mu CLIA Kit for Mucin 5 Subtype AC (MUC5AC) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA756Ra01 Recombinant Mucin 5 Subtype AC (MUC5AC) Positive Control; Immunogen; SDS-PAGE; WB.
RPA756Ra02 Recombinant Mucin 5 Subtype AC (MUC5AC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA756Ra01 Polyclonal Antibody to Mucin 5 Subtype AC (MUC5AC) WB; IHC; ICC; IP.
LAA756Ra71 Biotin-Linked Polyclonal Antibody to Mucin 5 Subtype AC (MUC5AC) WB; IHC; ICC.
MAA756Ra21 Monoclonal Antibody to Mucin 5 Subtype AC (MUC5AC) WB; IHC; ICC; IP.
PAA756Ra02 Polyclonal Antibody to Mucin 5 Subtype AC (MUC5AC) WB; IHC; ICC; IP.
Assay Kits SEA756Ra ELISA Kit for Mucin 5 Subtype AC (MUC5AC) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA756Ra CLIA Kit for Mucin 5 Subtype AC (MUC5AC) Chemiluminescent immunoassay for Antigen Detection.
  1. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region."Biochem. J. 358:763-772(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts."J. Biol. Chem. 273:6812-6820(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains."Biochem. J. 308:831-838(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Proteolytic fragmentation and peptide mapping of human carboxyamidomethylated tracheobronchial mucin."J. Biol. Chem. 264:8193-8199(1989) [PubMed] [Europe PMC] [Abstract]
  6. "Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family."Biochem. J. 332:729-738(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5)."J. Biol. Chem. 269:12932-12939(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of a mucin cDNA clone isolated from HT-29 mucus secreting cells: the 3' end of MUC5AC?"J. Biol. Chem. 270:13665-13673(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Cleavage in the GDPH sequence of the C-terminal cysteine-rich part of the human MUC5AC mucin."Biochem. J. 399:121-129(2006) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  12. "In vivo glycosylation of mucin tandem repeats."Glycobiology 11:459-471(2001) [PubMed] [Europe PMC] [Abstract]
  13. "The MUC5AC glycoprotein is the primary receptor for Helicobacter pylori in the human stomach."Helicobacter 8:521-532(2003) [PubMed] [Europe PMC] [Abstract]
  14. "C-Mannosylation of MUC5AC and MUC5B Cys subdomains."Glycobiology 14:325-337(2004) [PubMed] [Europe PMC] [Abstract]