Trefoil Factor 2 (TFF2)

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SML1; SP; Spasmolytic Protein 1; Spasmolysin; Spasmolytic polypeptide

Trefoil Factor 2 (TFF2)

Trefoil factor 2 is aMember of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.

The porcine gene was used to clone human and mouse SP cDNAs from stomach cDNA libraries. The human SP cDNA encodes a predicted 129-amino acid protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA748Hu01 Recombinant Trefoil Factor 2 (TFF2) Positive Control; Immunogen; SDS-PAGE; WB.
APA748Hu01 Active Trefoil Factor 2 (TFF2) Cell culture; Activity Assays.
Antibodies PAA748Hu01 Polyclonal Antibody to Trefoil Factor 2 (TFF2) WB; IHC; ICC; IP.
MAA748Hu22 Monoclonal Antibody to Trefoil Factor 2 (TFF2) WB; IHC; ICC; IP.
LAA748Hu71 Biotin-Linked Polyclonal Antibody to Trefoil Factor 2 (TFF2) WB; IHC; ICC.
Assay Kits SEA748Hu ELISA Kit for Trefoil Factor 2 (TFF2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA748Mu01 Recombinant Trefoil Factor 2 (TFF2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA748Mu02 Recombinant Trefoil Factor 2 (TFF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA748Mu01 Polyclonal Antibody to Trefoil Factor 2 (TFF2) WB; IHC; ICC; IP.
LAA748Mu71 Biotin-Linked Polyclonal Antibody to Trefoil Factor 2 (TFF2) WB; IHC; ICC.
PAA748Mu02 Polyclonal Antibody to Trefoil Factor 2 (TFF2) WB; IHC; ICC; IP.
Assay Kits SEA748Mu ELISA Kit for Trefoil Factor 2 (TFF2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA748Ra01 Recombinant Trefoil Factor 2 (TFF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA748Ra01 Polyclonal Antibody to Trefoil Factor 2 (TFF2) WB; IHC; ICC; IP.
LAA748Ra71 Biotin-Linked Polyclonal Antibody to Trefoil Factor 2 (TFF2) WB; IHC; ICC.
MAA748Ra21 Monoclonal Antibody to Trefoil Factor 2 (TFF2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Trefoil Factor 2 (TFF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trefoil Factor 2 (TFF2) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trefoil Factor 2 (TFF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trefoil Factor 2 (TFF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trefoil Factor 2 (TFF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trefoil Factor 2 (TFF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trefoil Factor 2 (TFF2) ELISA Kit Customized Service Offer
  1. "hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma."EMBO J. 9:407-414(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3."Genomics 40:200-202(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region."Genomics 68:22-29(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]