Complement Component 7 (C7)
  • C7 is a single-chain plasma glycoprotein involved in the cytolytic phase of complement activation (Hobart et al., 1995). Mutations in the C7 gene cause C7 deficiency, a defect associated with increased susceptibility to neisserial recurrent infections (Barroso et al., 2004). Hobart et al. (1978) identified 3 structural forms of C7, concluded they are the products of 3 codominant alleles at an autosomal locus, and found that the C6 and C7 loci are closely linked to each other but not to the HLA complex. By Southern blot analysis of hybrid cell DNAs using cDNA probes, Jeremiah et al. demonstrated that the human C6 and C7 genes are located on chromosome 5. See Coto et al. (1991) for linkage information indicating that C6, C7, and C9 are closely situated; C9 was mapped to 5p13.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA731Hu01 Recombinant Complement Component 7 (C7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA731Hu01 Polyclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IP.
MAA731Hu22 Monoclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IP.
Assay Kits SEA731Hu ELISA Kit for Complement Component 7 (C7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Complement Component 7 (C7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Complement Component 7 (C7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complement Component 7 (C7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Complement Component 7 (C7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Component 7 (C7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA731Ra01 Recombinant Complement Component 7 (C7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA731Ra01 Polyclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Complement Component 7 (C7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Component 7 (C7) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA731Po01 Recombinant Complement Component 7 (C7) Positive Control; Immunogen; SDS-PAGE; WB.
RPA731Po02 Recombinant Complement Component 7 (C7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA731Po01 Polyclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IP.
PAA731Po02 Polyclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IP.
LAA731Po81 FITC-Linked Polyclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IF.
LAA731Po71 Biotin-Linked Polyclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC.
Assay Kits SEA731Po ELISA Kit for Complement Component 7 (C7) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  9. "Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement."J. Biol. Chem. 284:19637-19649(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular bases of combined subtotal deficiencies of C6 and C7: their effects in combination with other C6 and C7 deficiencies."J. Immunol. 157:3648-3657(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Molecular bases of C7 deficiency: three different defects."J. Immunol. 159:1019-1026(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Complement C7 deficiency: seven further molecular defects and their associated marker haplotypes."Hum. Genet. 103:513-519(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative detection of single amino acid polymorphisms by targeted proteomics."J. Mol. Cell Biol. 3:309-315(2011) [PubMed] [Europe PMC] [Abstract]