Prostacyclin (PGI2)

Prostacyclin is produced in endothelial cells from prostaglandin H2 (PGH2) by the action of the enzyme prostacyclin synthase. Although prostacyclin is considered an independent mediator, it is called PGI2 in eicosanoid nomenclature, and is a member of the prostanoids.The series-3 prostaglandin PGH3 also follows the prostacyclin synthase pathway, yielding another prostacyclin, PGI3. The unqualified term 'prostacyclin' usually refers to PGI2. PGI2 is derived from the ω-6 arachidonic acid. PGI3 is derived from the ω-3 EPA. Prostacyclin (PGI2) chiefly prevents formation of the platelet plug involved in primary hemostasis (a part of blood clot formation). It does this by inhibiting platelet activation. It is also an effective vasodilator. Prostacyclin's interactions in contrast to thromboxane (TXA2), another eicosanoid, strongly suggest a mechanism of cardiovascular homeostasis between the two hormones in relation to vascular damage.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Prostacyclin (PGI2) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prostacyclin (PGI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostacyclin (PGI2) Polyclonal Antibody Customized Service Offer
Assay Kits CEA727Ge ELISA Kit for Prostacyclin (PGI2) Enzyme-linked immunosorbent assay for Antigen Detection.