G Protein Coupled Receptor 44 (GPR44)

[Edit]

CD294; PTGDR2; CRTH2; Prostaglandin D2 receptor 2; Chemoattractant Receptor Homologous Molecule Expressed On T Helper Type 2 Cells

G Protein Coupled Receptor 44 (GPR44)

G protein-coupled receptors (GPCRs), such as GPR44, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.GPR44 has recently been found to belong to the prostanoid receptor family and named DP2, with this becoming the official IUPHAR nomenclature.GPR44 encodes a 472-amino acid protein that is closely related to chemoattractant receptors. Northern blot analysis revealed a 3.5-kb GPR44 transcript primarily in thalamus, frontal cortex, pons, and hippocampus and at lower levels in hypothalamus and caudate/putamen. A 3.4-kb transcript was detected in fetal liver, leukocytes, and thymus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins CPA720Hu21 OVA Conjugated G Protein Coupled Receptor 44 (GPR44) Immunogen; SDS-PAGE; WB.
Antibodies PAA720Hu01 Polyclonal Antibody to G Protein Coupled Receptor 44 (GPR44) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 44 (GPR44) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 44 (GPR44) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor 44 (GPR44) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor 44 (GPR44) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor 44 (GPR44) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 44 (GPR44) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 44 (GPR44) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor 44 (GPR44) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor 44 (GPR44) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor 44 (GPR44) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 44 (GPR44) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 44 (GPR44) ELISA Kit Customized Service Offer
  1. "Discovery of three novel orphan G-protein-coupled receptors."Genomics 56:12-21(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Selective expression of a novel surface molecule by human Th2 cells in vivo."J. Immunol. 162:1278-1286(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor."Blood 98:1942-1948(2001) [PubMed] [Europe PMC] [Abstract]
  6. "A novel surface molecule of Th2- and Tc2-type cells, CRTH2 expression on human peripheral and decidual CD4+ and CD8+ T cells during the early stage of pregnancy."Clin. Exp. Immunol. 123:105-111(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2."J. Exp. Med. 193:255-261(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2."Br. J. Pharmacol. 137:1163-1172(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2)."Biochem. Pharmacol. 73:843-853(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2."Eur. J. Pharmacol. 557:115-123(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif."Eur. J. Pharmacol. 630:10-18(2010) [PubMed] [Europe PMC] [Abstract]