Delta-Sleep Inducing Peptide (dSIP)

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DSIPI; TSC22D3; DIP; GILZ; TSC-22R; hDIP; TSC22 Domain Family Protein 3; Glucocorticoid-Induced Leucine Zipper; Delta Sleep Inducing Peptide,Immunoreactor

Delta-Sleep Inducing Peptide (dSIP)

Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities. DSIP was discovered by G.Schoeneberger and M.Monnier in 1974; first research aimed at it's somnogenous properties lead to the dubious results. Instead it was demonstrated by the works of different teams that DSIP actually plays a important role in the stress-resistance. DSIP has stress-protective, antiseizure, and immunomodulating effects. It has been demonstrated that DSIP have significant geroprotective effect. K.V. Sudakov views DSIP as one of the 4 main substances, responsible for the stress-resistance of the organism, another 3 being substance P, prolactin and beta-endorphin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA708Hu01 Recombinant Delta-Sleep Inducing Peptide (dSIP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA708Hu01 Polyclonal Antibody to Delta-Sleep Inducing Peptide (dSIP) WB; ICC; IHC-P; IHC-F; ELISA.
MAA708Hu22 Monoclonal Antibody to Delta-Sleep Inducing Peptide (dSIP) WB; IHC; ICC; IP.
Assay Kits CEA708Hu ELISA Kit for Delta-Sleep Inducing Peptide (dSIP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA708Mu01 Recombinant Delta-Sleep Inducing Peptide (dSIP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA708Mu01 Polyclonal Antibody to Delta-Sleep Inducing Peptide (dSIP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Delta-Sleep Inducing Peptide (dSIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Delta-Sleep Inducing Peptide (dSIP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Delta-Sleep Inducing Peptide (dSIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Delta-Sleep Inducing Peptide (dSIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Delta-Sleep Inducing Peptide (dSIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Delta-Sleep Inducing Peptide (dSIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Delta-Sleep Inducing Peptide (dSIP) ELISA Kit Customized Service Offer

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins CPA708Rb21 OVA Conjugated Delta-Sleep Inducing Peptide (dSIP) Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Delta-Sleep Inducing Peptide (dSIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Delta-Sleep Inducing Peptide (dSIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Delta-Sleep Inducing Peptide (dSIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Delta-Sleep Inducing Peptide (dSIP) ELISA Kit Customized Service Offer
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  2. "Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene."Cell Death Differ. 8:201-203(2001) [PubMed] [Europe PMC] [Abstract]
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  6. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
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  8. "Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappa B."Blood 98:743-753(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10."Blood 101:729-738(2003) [PubMed] [Europe PMC] [Abstract]
  10. "GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis."Blood 104:215-223(2004) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]