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Thioredoxin Reductase 1 (TXNRD1)

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TrxR1; TR1; GRIM12; KDRF; TRXR-1; TXNR; Gene associated with retinoic and interferon-induced mortality 12 protein; KM-102-derived reductase-like factor

Thioredoxin Reductase 1 (TXNRD1)
CCC A703
HGNC 12437
MGI 1354175
PubMed 19838062
RGD 61959
UniProt Q16881
Wiki TXNRD1

Thioredoxin reductase 1, cytoplasmic is a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA703Hu01 Recombinant Thioredoxin Reductase 1 (TXNRD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA703Hu01 Polyclonal Antibody to Thioredoxin Reductase 1 (TXNRD1) WB; IHC; ICC; IP.
MAA703Hu22 Monoclonal Antibody to Thioredoxin Reductase 1 (TXNRD1) WB; IHC; ICC; IP.
LAA703Hu71 Biotin-Linked Polyclonal Antibody to Thioredoxin Reductase 1 (TXNRD1) WB; IHC; ICC.
Assay Kits SEA703Hu ELISA Kit for Thioredoxin Reductase 1 (TXNRD1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA703Hu CLIA Kit for Thioredoxin Reductase 1 (TXNRD1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA703Mu01 Recombinant Thioredoxin Reductase 1 (TXNRD1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA703Mu02 Recombinant Thioredoxin Reductase 1 (TXNRD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA703Mu01 Polyclonal Antibody to Thioredoxin Reductase 1 (TXNRD1) WB; IHC; ICC; IP.
PAA703Mu02 Polyclonal Antibody to Thioredoxin Reductase 1 (TXNRD1) WB; IHC; ICC; IP.
Assay Kits SEA703Mu ELISA Kit for Thioredoxin Reductase 1 (TXNRD1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA703Ra01 Recombinant Thioredoxin Reductase 1 (TXNRD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA703Ra01 Polyclonal Antibody to Thioredoxin Reductase 1 (TXNRD1) WB; IHC; ICC; IP.
Assay Kits SEA703Ra ELISA Kit for Thioredoxin Reductase 1 (TXNRD1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  10. "Alternative splicing involving the thioredoxin reductase module in mammals: a glutaredoxin-containing thioredoxin reductase 1."Biochemistry 43:12177-12188(2004) [PubMed] [Europe PMC] [Abstract]
  11. "An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling."J. Biol. Chem. 279:38721-38729(2004) [PubMed] [Europe PMC] [Abstract]
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  19. "The structure of human thioredoxin reductase 1 provides insights into C-terminal rearrangements during catalysis."J. Mol. Biol. 370:116-127(2007) [PubMed] [Europe PMC] [Abstract]