Toll Like Receptor 6 (TLR6)

Toll Like Receptor 6 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. By screening a human placenta library with a mouse Tlr6 probe, Takeuchi et al. (1999) isolated a cDNA encoding human TLR6. The deduced 796-amino acid type I transmembrane protein, which is 74% identical to mouse Tlr6 and 69% identical to TLR1, contains an N-terminal signal peptide, 20 tandemly repeated extracellular leucine-rich motifs, and a cytoplasmic domain homologous to IL1R, as seen in other TLRs. RT-PCR analysis detected Tlr6 in mouse thymus, spleen, ovary, and lung.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA683Hu01 Recombinant Toll Like Receptor 6 (TLR6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA683Hu01 Polyclonal Antibody to Toll Like Receptor 6 (TLR6) WB; ICC; IHC-P; IHC-F; ELISA.
MAA683Hu22 Monoclonal Antibody to Toll Like Receptor 6 (TLR6) WB; IHC; ICC; IP.
Assay Kits SEA683Hu ELISA Kit for Toll Like Receptor 6 (TLR6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA683Mu01 Recombinant Toll Like Receptor 6 (TLR6) Positive Control; Immunogen; SDS-PAGE; WB.
RPA683Mu02 Recombinant Toll Like Receptor 6 (TLR6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA683Mu01 Polyclonal Antibody to Toll Like Receptor 6 (TLR6) WB; IHC; ICC; IP.
PAA683Mu02 Polyclonal Antibody to Toll Like Receptor 6 (TLR6) WB; IHC; ICC; IP.
Assay Kits SEA683Mu ELISA Kit for Toll Like Receptor 6 (TLR6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Toll Like Receptor 6 (TLR6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Toll Like Receptor 6 (TLR6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Toll Like Receptor 6 (TLR6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Toll Like Receptor 6 (TLR6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Toll Like Receptor 6 (TLR6) ELISA Kit Customized Service Offer
  1. "TLR6: a novel member of an expanding Toll-like receptor family."Gene 231:59-65(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Natural selection in the TLR-related genes in the course of primate evolution."Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling."J. Immunol. 167:987-994(2001) [PubMed] [Europe PMC] [Abstract]
  6. "CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer."Nat. Immunol. 11:155-161(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family."Hum. Mutat. 32:643-652(2011) [PubMed] [Europe PMC] [Abstract]