Dopamine Receptor D2 (DRD2)

D2 (DRD2). There is a short version of D2 (D2Sh) and a long version of D2 (D2Lh): The D2Sh are pre-synaptic situated, having modulatory functions (called autoreceptor, they regulate the neurotransmission by feed-back mechanisms, i.e., synthesis, storage and release of dopamine into the synaptic cleft).

The D2Lh may have the classic function of a post-synaptic receptor, i.e., keep going on the neurotransmission (excitatory or inhibitory) once blocked by a receptor antagonist or stimulated by the endogenous neurotransmitter itself or a synthetic full or partial agonist.D2-like activation is coupled to the G protein Gαi, which subsequently increases phosphodiesterase activity. Phosphodiesterases break down cAMP, producing an inhibitory effect in neurons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA673Hu01 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA673Hu01 Polyclonal Antibody to Dopamine Receptor D2 (DRD2) WB; IHC; ICC; IP.
MAA673Hu22 Monoclonal Antibody to Dopamine Receptor D2 (DRD2) WB; IHC; ICC; IP.
Assay Kits SEA673Hu ELISA Kit for Dopamine Receptor D2 (DRD2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dopamine Receptor D2 (DRD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dopamine Receptor D2 (DRD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dopamine Receptor D2 (DRD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dopamine Receptor D2 (DRD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dopamine Receptor D2 (DRD2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA673Ra01 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA673Ra01 Polyclonal Antibody to Dopamine Receptor D2 (DRD2) WB; IHC; ICC; IP.
MAA673Ra21 Monoclonal Antibody to Dopamine Receptor D2 (DRD2) WB; IHC; ICC; IP.
Assay Kits SEA673Ra ELISA Kit for Dopamine Receptor D2 (DRD2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA673Ca01 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA673Ca01 Polyclonal Antibody to Dopamine Receptor D2 (DRD2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Dopamine Receptor D2 (DRD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dopamine Receptor D2 (DRD2) ELISA Kit Customized Service Offer
  1. "The major dopamine D2 receptor: molecular analysis of the human D2A subtype."DNA 8:683-689(1989) [PubMed] [Europe PMC] [Abstract]
  2. "The dopamine D2 receptor: two molecular forms generated by alternative splicing."EMBO J. 8:4025-4034(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Human retina D2 receptor cDNAs have multiple polyadenylation sites and differ from a pituitary clone at the 5' non-coding region."Nucleic Acids Res. 18:1299-1299(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning of the cDNA and gene for a human D2 dopamine receptor."Proc. Natl. Acad. Sci. U.S.A. 86:9762-9766(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular cloning and expression of a dopamine D2 receptor from human retina."Mol. Pharmacol. 37:1-6(1990) [PubMed] [Europe PMC] [Abstract]
  6. "DNA homology screening: isolation and characterization of the human D2A dopamine receptor subtype."Adv. Second Messenger Phosphoprotein Res. 24:9-14(1990) [PubMed] [Europe PMC] [Abstract]
  7. "Structure and expression of human and rat D2 dopamine receptor genes."Neurochem. Int. 21:91-98(1992) [PubMed] [Europe PMC] [Abstract]
  8. "D2 dopamine receptors in the human retina: cloning of cDNA and localization of mRNA."Cell. Mol. Neurobiol. 11:437-453(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Schizophrenia: normal sequence in the dopamine D2 receptor region that couples to G-proteins. DNA polymorphisms in D2."Neuropsychopharmacology 8:137-142(1993) [PubMed] [Europe PMC] [Abstract]
  10. "New dopamine receptor, D2(Longer), with unique TG splice site, in human brain."Brain Res. Mol. Brain Res. 76:132-141(2000) [PubMed] [Europe PMC] [Abstract]
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)."Biochem. Pharmacol. 69:1451-1461(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool."J. Cell Sci. 120:2171-2178(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions."Biochem. Biophys. Res. Commun. 404:928-934(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors."Neuropharmacology 61:770-777(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity."Proc. Natl. Acad. Sci. U.S.A. 104:2001-2006(2007) [PubMed] [Europe PMC] [Abstract]
  17. ErratumProc. Natl. Acad. Sci. U.S.A. 109:1808-1808(2012) [PubMed] [Europe PMC] [Abstract]
  18. "A structural polymorphism of human dopamine D2 receptor, D2(Ser311->Cys)."Biochem. Biophys. Res. Commun. 196:1369-1375(1993) [PubMed] [Europe PMC] [Abstract]
  19. "Association of a missense change in the D2 dopamine receptor with myoclonus dystonia."Proc. Natl. Acad. Sci. U.S.A. 96:5173-5176(1999) [PubMed] [Europe PMC] [Abstract]
  20. "Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics."Am. J. Med. Genet. B Neuropsychiatr. Genet. 132:46-49(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Evaluation of the role of the D2 dopamine receptor in myoclonus dystonia." Ann. Neurol. 47:369-373(2000) [PubMed] [Europe PMC] [Abstract]
  22. "A population-specific HTR2B stop codon predisposes to severe impulsivity."Nature 468:1061-1066(2010) [PubMed] [Europe PMC] [Abstract]