Glutathione S Transferase Alpha 4 (GSTa4)

Glutathione S Transferase Alpha 4 is a glutathione S-tranferase belonging to the alpha class.GSTA4 shows very high activity with reactive carbonyl compounds such as alk-2-enals.GSTA4 is highly effective in catalyzing the conjugate addition of reduced glutathione to 4-hydroxynonenal, an important product of peroxidative degradation of arachidonic acid and a commonly used biomarker for oxidative damage in tissue.Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis hence reduced expression of the GSTA4 enzyme may have pathophysiological consequences. The expression of this gene is decreased drastically among burn and trauma victims.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA659Hu01 Recombinant Glutathione S Transferase Alpha 4 (GSTa4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA659Hu01 Polyclonal Antibody to Glutathione S Transferase Alpha 4 (GSTa4) WB; ICC; IHC-P; IHC-F; ELISA.
MAA659Hu22 Monoclonal Antibody to Glutathione S Transferase Alpha 4 (GSTa4) WB; IHC; ICC; IP.
LAA659Hu71 Biotin-Linked Polyclonal Antibody to Glutathione S Transferase Alpha 4 (GSTa4) WB; IHC; ICC.
LAA659Hu81 FITC-Linked Polyclonal Antibody to Glutathione S Transferase Alpha 4 (GSTa4) WB; IHC; ICC; IF.
Assay Kits SEA659Hu ELISA Kit for Glutathione S Transferase Alpha 4 (GSTa4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA659Mu01 Recombinant Glutathione S Transferase Alpha 4 (GSTa4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA659Mu02 Recombinant Glutathione S Transferase Alpha 4 (GSTa4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA659Mu01 Polyclonal Antibody to Glutathione S Transferase Alpha 4 (GSTa4) WB; IHC; ICC; IP.
LAA659Mu71 Biotin-Linked Polyclonal Antibody to Glutathione S Transferase Alpha 4 (GSTa4) WB; IHC; ICC.
LAA659Mu81 FITC-Linked Polyclonal Antibody to Glutathione S Transferase Alpha 4 (GSTa4) WB; IHC; ICC; IF.
PAA659Mu02 Polyclonal Antibody to Glutathione S Transferase Alpha 4 (GSTa4) WB; IHC; ICC; IP.
Assay Kits SEA659Mu ELISA Kit for Glutathione S Transferase Alpha 4 (GSTa4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA659Ra01 Recombinant Glutathione S Transferase Alpha 4 (GSTa4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA659Ra01 Polyclonal Antibody to Glutathione S Transferase Alpha 4 (GSTa4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Glutathione S Transferase Alpha 4 (GSTa4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutathione S Transferase Alpha 4 (GSTa4) ELISA Kit Customized Service Offer
  1. "Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation."Biochem. J. 330:175-179(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4."Biochem. J. 330:827-831(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of a novel human glutathione S-transferase using bioinformatics."Arch. Biochem. Biophys. 352:306-313(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic organization, 5'-flanking region and chromosomal localization of the human glutathione transferase A4 gene."Biochem. J. 336:437-442(1998) [PubMed] [Europe PMC] [Abstract]
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  7. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products."J. Mol. Biol. 288:427-439(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal."Biochemistry 49:1541-1548(2010) [PubMed] [Europe PMC] [Abstract]