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Receptor For Advanced Glycation Endproducts (RAGE)

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AGER; Receptor For Advanced Glycation Endproducts

Receptor For Advanced Glycation Endproducts (RAGE)
CCC A645
HGNC 320
MGI 893592
PubMed 21521347
RGD 69258
UniProt Q15109
Wiki RAGE

RAGE, the receptor for advanced glycation endproducts is a 35kD transmembrane receptor of the immunoglobulin super family which was first characterized in 1992 by Neeper et al.. Its name comes from its ability to bind advanced glycation endproducts (AGE), a heterogeneous group of non-enzymatically altered proteins. Besides AGEs, RAGE is also able to bind other ligands and is thus often referred to as a pattern recognition receptor.The interaction between RAGE and its ligands is thought to result in pro-inflammatory gene activation. Due to an enhanced level of RAGE ligands in diabetes or other chronic disorders, this receptor is hypothesised to have a causative effect in a range of inflammatory diseases such as diabetic complications, Alzheimer's disease and even some tumors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA645Hu01 Recombinant Receptor For Advanced Glycation Endproducts (RAGE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA645Hu01 Polyclonal Antibody to Receptor For Advanced Glycation Endproducts (RAGE) WB; IHC
MAA645Hu22 Monoclonal Antibody to Receptor For Advanced Glycation Endproducts (RAGE) WB; IHC; ICC; IP.
Assay Kits SEA645Hu ELISA Kit for Receptor For Advanced Glycation Endproducts (RAGE) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA645Mu01 Recombinant Receptor For Advanced Glycation Endproducts (RAGE) Positive Control; Immunogen; SDS-PAGE; WB.
RPA645Mu02 Recombinant Receptor For Advanced Glycation Endproducts (RAGE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA645Mu01 Polyclonal Antibody to Receptor For Advanced Glycation Endproducts (RAGE) WB; IHC; ICC; IP.
PAA645Mu02 Polyclonal Antibody to Receptor For Advanced Glycation Endproducts (RAGE) WB; IHC; ICC; IP.
Assay Kits SEA645Mu ELISA Kit for Receptor For Advanced Glycation Endproducts (RAGE) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA645Mu CLIA Kit for Receptor For Advanced Glycation Endproducts (RAGE) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA645Ra01 Recombinant Receptor For Advanced Glycation Endproducts (RAGE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA645Ra01 Polyclonal Antibody to Receptor For Advanced Glycation Endproducts (RAGE) WB; IHC; ICC; IP.
Assay Kits SEA645Ra ELISA Kit for Receptor For Advanced Glycation Endproducts (RAGE) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins."J. Biol. Chem. 267:14998-15004(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3."Genomics 23:408-419(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury."Biochem. J. 370:1097-1109(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Identification, classification, and expression of RAGE gene splice variants."FASEB J. 22:1572-1580(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Alternative splicing of the RAGE cytoplasmic domain regulates cell signaling and function."PLoS ONE 8:E78267-E78267(2013) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy."Diabetes 50:1505-1511(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function."BMC Biochem. 10:11-11(2009) [PubMed] [Europe PMC] [Abstract]
  12. "RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease."FASEB J. 24:1043-1055(2010) [PubMed] [Europe PMC] [Abstract]
  13. "S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE)."PLoS ONE 6:E19375-E19375(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis."PLoS ONE 7:E50736-E50736(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Solution structure of the third Ig-like domain from human advanced glycosylation end product-specific receptor."Submitted (APR-2008) to the PDB data bank
  16. "The 1.5 A crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding."J. Biol. Chem. 285:40762-40770(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Structural basis for ligand recognition and activation of RAGE."Structure 18:1342-1352(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Advanced glycation end product recognition by the receptor for AGEs."Structure 19:722-732(2011) [PubMed] [Europe PMC] [Abstract]