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Glutathione S Transferase Theta 1 (GSTt1)

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GST-T1

Glutathione S Transferase Theta 1 (GSTt1)
CCC A622
HGNC 4641
MGI 107379
PubMed 15612961
RGD 2765
UniProt P30711
Wiki GSTT1

Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta.

The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA622Hu01 Recombinant Glutathione S Transferase Theta 1 (GSTt1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA622Hu01 Polyclonal Antibody to Glutathione S Transferase Theta 1 (GSTt1) WB; IHC; ICC; IP.
MAA622Hu22 Monoclonal Antibody to Glutathione S Transferase Theta 1 (GSTt1) WB; IHC; ICC; IP.
LAA622Hu72 Biotin-Linked Monoclonal Antibody to Glutathione S Transferase Theta 1 (GSTt1) WB; IHC; ICC.
LAA622Hu71 Biotin-Linked Polyclonal Antibody to Glutathione S Transferase Theta 1 (GSTt1) WB; IHC; ICC.
LAA622Hu82 FITC-Linked Monoclonal Antibody to Glutathione S Transferase Theta 1 (GSTt1) WB; IHC; ICC; IF.
LAA622Hu81 FITC-Linked Polyclonal Antibody to Glutathione S Transferase Theta 1 (GSTt1) WB; IHC; ICC; IF.
Assay Kits SEA622Hu ELISA Kit for Glutathione S Transferase Theta 1 (GSTt1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA622Mu01 Recombinant Glutathione S Transferase Theta 1 (GSTt1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA622Mu01 Polyclonal Antibody to Glutathione S Transferase Theta 1 (GSTt1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Glutathione S Transferase Theta 1 (GSTt1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutathione S Transferase Theta 1 (GSTt1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA622Ra01 Recombinant Glutathione S Transferase Theta 1 (GSTt1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA622Ra01 Polyclonal Antibody to Glutathione S Transferase Theta 1 (GSTt1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Glutathione S Transferase Theta 1 (GSTt1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutathione S Transferase Theta 1 (GSTt1) ELISA Kit Customized Service Offer
  1. "Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism."Biochem. J. 300:271-276(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Kinetic characterization of recombinant human glutathione transferase T1-1, a polymorphic detoxication enzyme."Arch. Biochem. Biophys. 348:247-254(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation."Pharmacogenetics 10:557-565(2000) [PubMed] [Europe PMC] [Abstract]
  4. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Theta, a new class of glutathione transferases purified from rat and man."Biochem. J. 274:409-414(1991) [PubMed] [Europe PMC] [Abstract]
  8. "The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human."Biochem. J. 318:297-303(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Residue 234 is a master switch of the alternative-substrate activity profile of human and rodent theta class glutathione transferase T1-1."Biochim. Biophys. Acta 1800:466-473(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Structural basis of the suppressed catalytic activity of wild-type human glutathione transferase T1-1 compared to its W234R mutant."J. Mol. Biol. 355:96-105(2006) [PubMed] [Europe PMC] [Abstract]