Cyclin D2 (CCND2)

Cyclin D2 is a protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA586Hu01 Recombinant Cyclin D2 (CCND2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA586Hu01 Polyclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IP.
MAA586Hu22 Monoclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IP.
Assay Kits SEA586Hu ELISA Kit for Cyclin D2 (CCND2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA586Mu01 Recombinant Cyclin D2 (CCND2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA586Mu01 Polyclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cyclin D2 (CCND2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin D2 (CCND2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin D2 (CCND2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin D2 (CCND2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin D2 (CCND2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin D2 (CCND2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin D2 (CCND2) ELISA Kit Customized Service Offer
  1. "Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins."Genomics 13:575-584(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines."Oncogene 8:1049-1054(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Genomic organization, chromosomal localization, and independent expression of human cyclin D genes."Genomics 13:565-574(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition."Cell Struct. Funct. 33:171-183(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Human and mouse cyclin D2 splice variants: transforming activity and subcellular localization."Oncogene 27:1253-1262(2008) [PubMed] [Europe PMC] [Abstract]
  9. "F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation."Blood 119:3132-3141(2012) [PubMed] [Europe PMC] [Abstract]
  10. "De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome." Nat. Genet. 46:510-515(2014) [PubMed] [Europe PMC] [Abstract]