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Cyclin D1 (CCND1)

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CCN-D1; BCL1; PRAD1; U21B31; G1/S-Specific Cyclin-D1; Parathyroid Adenomatosis 1; B-Cell CLL/Lymphoma 1; G1/S-Specific Cyclin D1; PRAD1 oncogene

Cyclin D1 (CCND1)
CCC A585
HGNC 1582
MGI 88313
PubMed 12432268
RGD 68384
UniProt P24385
Wiki Cyclin_D1

Cyclin D1 belongs to the family of cyclin proteins which function as the regulatory subunits of cyclin/cyclin dependent kinase (Cdk) holoenzymes that regulate entry into and progression through the cell cycle. Cyclin D1 expression is induced upon stimulation by growth factors (e.g.EGF, IGF-I/II), amino acids, hormones, and oncogenes such as Ras, Src, ErbB2, and SV40 T antigen. Cdk4 and Cdk6 can partner with Cyclin D1 in early to mid-G1 phase to phosphorylate and inactivate the cell-cycle inhibitory function of the retinoblastoma protein (pRB) in cooperation with Cyclin E/Cdk2. Cyclin D1 is also known to modulate local chromatin structure and transcription of genes involved in proliferation and differentiation through CDK-independent association with histone acetylases (e.g. CBP, P/CAF) and deacetylases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA585Hu01 Recombinant Cyclin D1 (CCND1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA585Hu01 Polyclonal Antibody to Cyclin D1 (CCND1) WB
MAA585Hu22 Monoclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IP.
Assay Kits SEA585Hu ELISA Kit for Cyclin D1 (CCND1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA585Mu01 Recombinant Cyclin D1 (CCND1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA585Mu02 Recombinant Cyclin D1 (CCND1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA585Mu01 Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IP.
LAA585Mu71 Biotin-Linked Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC.
LAA585Mu81 FITC-Linked Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IF.
PAA585Mu02 Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IP.
Assay Kits SEA585Mu ELISA Kit for Cyclin D1 (CCND1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA585Ra01 Recombinant Cyclin D1 (CCND1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA585Ra01 Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IP.
LAA585Ra71 Biotin-Linked Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC.
LAA585Ra81 FITC-Linked Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IF.
Assay Kits SEA585Ra ELISA Kit for Cyclin D1 (CCND1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin D1 (CCND1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin D1 (CCND1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin D1 (CCND1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin D1 (CCND1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin D1 (CCND1) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA585Bo01 Recombinant Cyclin D1 (CCND1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA585Bo01 Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cyclin D1 (CCND1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin D1 (CCND1) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA585Ga01 Recombinant Cyclin D1 (CCND1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA585Ga01 Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IP.
LAA585Ga71 Biotin-Linked Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC.
LAA585Ga81 FITC-Linked Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IF.
MAA585Ga21 Monoclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cyclin D1 (CCND1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin D1 (CCND1) ELISA Kit Customized Service Offer
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  2. "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast."Cell 66:1197-1206(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Human D-type cyclin."Cell 65:691-699(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of a candidate bcl-1 gene."Mol. Cell. Biol. 11:4846-4853(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias."Blood 83:3689-3696(1994) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint."Genes Chromosomes Cancer 7:89-95(1993) [PubMed] [Europe PMC] [Abstract]
  8. "CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1."Oncogene 9:71-79(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines."Blood 88:674-681(1996) [PubMed] [Europe PMC] [Abstract]
  10. "New functional activities for the p21 family of CDK inhibitors."Genes Dev. 11:847-862(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286."J. Biol. Chem. 275:12074-12079(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Cyclin-dependent kinases regulate the antiproliferative function of Smads."Nature 430:226-231(2004) [PubMed] [Europe PMC] [Abstract]
  13. "INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases."Biochem. J. 397:169-177(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription."J. Endocrinol. 198:29-39(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest."J. Biol. Chem. 284:5574-5581(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Suppression of cancer cell growth by promoting cyclin D1 degradation."Mol. Cell 36:469-476(2009) [PubMed] [Europe PMC] [Abstract]
  17. "F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage."Nature 459:722-725(2009) [PubMed] [Europe PMC] [Abstract]
  18. "NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor."Cell Cycle 10:3284-3299(2011) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  20. "Crystal structure of human CDK4 in complex with a D-type cyclin."Proc. Natl. Acad. Sci. U.S.A. 106:4166-4170(2009) [PubMed] [Europe PMC] [Abstract]