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Interleukin 1 Delta (FIL1d)

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IL1HY1; IL36RN; IL36Ra; IL1RP3; IL1L1; IL1F5; Interleukin 1 Family, Member 5; Interleukin-1 HY1; IL-1 Related Protein 3; Interleukin 36 Receptor Antagonist

Interleukin 1 Delta (FIL1d)
CCC A566
HGNC 15561
MGI 1859325
PubMed 11466363
RGD 1311212
UniProt Q9UBH0
Wiki IL1F5

PCR analysis revealed expression in leukocytes, spleen, and brain as well as in fetal brain and most abundantly in a fetal skin library. RT-PCR analysis also established that IL1HY1 expression is amplified in a stimulated macrophage cell line.

By EST database searching, Smith et al. (2000) also identified a cDNA encoding IL1HY1, which they termed FIL1-delta. Modeling indicated that IL1HY1 has a conserved 12-stranded beta-trefoil structure. By searching EST databases for IL1-like ligands, Busfield et al. (2000) also cloned IL1HY1, which they designated IL1RP3. SDS-PAGE analysis indicated that IL1HY1 is expressed as a 23-kD protein. Northern blot analysis detected expression of a 2.8-kb transcript in placenta and uterus. In situ hybridization analysis revealed constitutive expression by keratinocytes in vitro.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA566Hu01 Recombinant Interleukin 1 Delta (FIL1d) Positive Control; Immunogen; SDS-PAGE; WB.
RPA566Hu02 Recombinant Interleukin 1 Delta (FIL1d) Positive Control; Immunogen; SDS-PAGE; WB.
APA566Hu01 Active Interleukin 1 Delta (FIL1d) Cell culture; Activity Assays.
Antibodies PAA566Hu01 Polyclonal Antibody to Interleukin 1 Delta (FIL1d) WB; IHC; ICC; IP.
MAA566Hu22 Monoclonal Antibody to Interleukin 1 Delta (FIL1d) WB; IHC; ICC; IP.
LAA566Hu71 Biotin-Linked Polyclonal Antibody to Interleukin 1 Delta (FIL1d) WB; IHC; ICC.
PAA566Hu02 Polyclonal Antibody to Interleukin 1 Delta (FIL1d) WB; IHC; ICC; IP.
Assay Kits SEA566Hu ELISA Kit for Interleukin 1 Delta (FIL1d) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA566Mu01 Recombinant Interleukin 1 Delta (FIL1d) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA566Mu01 Polyclonal Antibody to Interleukin 1 Delta (FIL1d) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interleukin 1 Delta (FIL1d) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 1 Delta (FIL1d) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 1 Delta (FIL1d) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 1 Delta (FIL1d) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 1 Delta (FIL1d) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 1 Delta (FIL1d) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 1 Delta (FIL1d) ELISA Kit Customized Service Offer
  1. "Four new members expand the IL-1 superfamily."J. Biol. Chem. 275:1169-1175(2000) [PubMed] [Europe PMC] [Abstract]
  2. "IL1HY1: a novel interleukin-1 receptor antagonist gene."Biochem. Biophys. Res. Commun. 263:702-706(1999) [PubMed] [Europe PMC] [Abstract]
  3. "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities."Eur. J. Immunol. 30:3299-3308(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2."J. Immunol. 167:1440-1446(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2."Genomics 66:213-216(2000) [PubMed] [Europe PMC] [Abstract]
  6. "A sequence-based map of the nine genes of the human interleukin-1 cluster."Genomics 79:718-725(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity."J. Biol. Chem. 286:42594-42602(2011) [PubMed] [Europe PMC] [Abstract]
  12. "The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses."Eur. J. Immunol. 43:416-426(2013) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis."Am. J. Hum. Genet. 89:432-437(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis." N. Engl. J. Med. 365:620-628(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Mutation analysis of the IL36RN gene in 14 Japanese patients with generalized pustular psoriasis."Hum. Mutat. 34:176-183(2013) [PubMed] [Europe PMC] [Abstract]