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Heparan Sulfate Proteoglycan (HSPG)

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SDC2; HSPG1; SYND2; Fibroglycan; Syndecan 2; Syndecan Proteoglycan 2; Heparan Sulfate Proteoglycan 1,Cell Surface-Associated; Heparan Sulphate Proteoglycan

Heparan Sulfate Proteoglycan (HSPG)
CCC A565
HGNC 10659
MGI 1349165
PubMed 19479939
RGD 3649
UniProt P34741
Wiki SDC2

Syndecan-2 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein.

The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.By Southern hybridization to a panel of human-mouse somatic cell hybrid DNA and by in situ hybridization, Marynen et al. (1989) showed that the heparan sulfate proteoglycan core protein maps to 8q22-q24.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA565Hu01 Recombinant Heparan Sulfate Proteoglycan (HSPG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA565Hu01 Polyclonal Antibody to Heparan Sulfate Proteoglycan (HSPG) WB; IHC; ICC; IP.
MAA565Hu22 Monoclonal Antibody to Heparan Sulfate Proteoglycan (HSPG) WB; IHC; ICC; IP.
LAA565Hu71 Biotin-Linked Polyclonal Antibody to Heparan Sulfate Proteoglycan (HSPG) WB; IHC; ICC.
LAA565Hu81 FITC-Linked Polyclonal Antibody to Heparan Sulfate Proteoglycan (HSPG) WB; IHC; ICC; IF.
Assay Kits SEA565Hu ELISA Kit for Heparan Sulfate Proteoglycan (HSPG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA565Mu01 Recombinant Heparan Sulfate Proteoglycan (HSPG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Heparan Sulfate Proteoglycan (HSPG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heparan Sulfate Proteoglycan (HSPG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heparan Sulfate Proteoglycan (HSPG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heparan Sulfate Proteoglycan (HSPG) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA565Ra01 Recombinant Heparan Sulfate Proteoglycan (HSPG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA565Ra01 Polyclonal Antibody to Heparan Sulfate Proteoglycan (HSPG) WB; IHC; ICC; IP.
Assay Kits SEA565Ra ELISA Kit for Heparan Sulfate Proteoglycan (HSPG) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. Prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell surface of human lung fibroblasts."J. Biol. Chem. 264:7017-7024(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]