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Plasminogen Activator Inhibitor 1 (PAI1)

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SERPINE1; PLANH1; Serpin Peptidase Inhibitor Clade E Member 1; Nexin,Plasminogen Activator Inhibitor Type 1 Serpin E1; Endothelial plasminogen activator inhibitor

Plasminogen Activator Inhibitor 1 (PAI1)
CCC A532
HGNC 8583
MGI 97608
PubMed 16273237
RGD 3249
UniProt P05121
Wiki PAI1

Plasminogen activator inhibitor-1 is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). It is a serine protease inhibitor (serpin) protein (SERPINE1).

The other PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by the placenta and only present in significant amounts during pregnancy. In addition, protease nexin acts as an inhibitor of tPA and urokinase. PAI-1, however, is the main inhibitor of the plasminogen activators. PAI-1 is mainly produced by the endothelium (cells lining blood vessels), but is also secreted by other tissue types, such as adipose tissue.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA532Hu01 Recombinant Plasminogen Activator Inhibitor 1 (PAI1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA532Hu02 Recombinant Plasminogen Activator Inhibitor 1 (PAI1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA532Hu61 Eukaryotic Plasminogen Activator Inhibitor 1 (PAI1) Positive Control; Immunogen; SDS-PAGE; WB.
APA532Hu61 Active Plasminogen Activator Inhibitor 1 (PAI1) Cell culture; Activity Assays.
Antibodies PAA532Hu01 Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC; IP.
MAA532Hu22 Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC/IF
LAA532Hu71 Biotin-Linked Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC.
LAA532Hu81 FITC-Linked Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC; IF.
MAA532Hu21 Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC; IP.
MAA532Hu24 Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC; IP.
LAA532Hu74 Biotin-Linked Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC.
MAA532Hu26 Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC; IP.
LAA532Hu76 Biotin-Linked Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC.
MAA532Hu23 Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC
PAA532Hu02 Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC; IP.
MAA532Hu27 Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC; IP.
MAA532Hu29 Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC; IP.
MAA532Hu25 Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC; IP.
Assay Kits SEA532Hu ELISA Kit for Plasminogen Activator Inhibitor 1 (PAI1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA532Hu CLIA Kit for Plasminogen Activator Inhibitor 1 (PAI1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA532Mu01 Recombinant Plasminogen Activator Inhibitor 1 (PAI1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA532Mu02 Recombinant Plasminogen Activator Inhibitor 1 (PAI1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA532Mu03 Recombinant Plasminogen Activator Inhibitor 1 (PAI1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA532Mu61 Eukaryotic Plasminogen Activator Inhibitor 1 (PAI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA532Mu01 Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC; IP.
PAA532Mu02 Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC; IP.
Assay Kits SEA532Mu ELISA Kit for Plasminogen Activator Inhibitor 1 (PAI1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA532Ra01 Recombinant Plasminogen Activator Inhibitor 1 (PAI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA532Ra01 Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC; IP.
MAA532Ra21 Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC; IP.
Assay Kits SEA532Ra ELISA Kit for Plasminogen Activator Inhibitor 1 (PAI1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA532Ra CLIA Kit for Plasminogen Activator Inhibitor 1 (PAI1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA532Rb01 Recombinant Plasminogen Activator Inhibitor 1 (PAI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA532Rb51 Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC; IP.
MAA532Rb21 Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC; IP.
Assay Kits SEA532Rb ELISA Kit for Plasminogen Activator Inhibitor 1 (PAI1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA532Si01 Recombinant Plasminogen Activator Inhibitor 1 (PAI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA532Si01 Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC; IP.
MAA532Si21 Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) WB; IHC; ICC; IP.
Assay Kits SEA532Si ELISA Kit for Plasminogen Activator Inhibitor 1 (PAI1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Plasminogen Activator Inhibitor 1 (PAI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Plasminogen Activator Inhibitor 1 (PAI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit Customized Service Offer
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  2. "Structure of the human plasminogen activator inhibitor 1 gene: nonrandom distribution of introns."Biochemistry 26:3763-3768(1987) [PubMed] [Europe PMC] [Abstract]
  3. "cDNA cloning of human plasminogen activator-inhibitor from endothelial cells."J. Clin. Invest. 78:1673-1680(1986) [PubMed] [Europe PMC] [Abstract]
  4. "Structure and expression of the human gene encoding plasminogen activator inhibitor, PAI-1."Gene 84:447-453(1989) [PubMed] [Europe PMC] [Abstract]
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  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor."Proc. Natl. Acad. Sci. U.S.A. 83:6776-6780(1986) [PubMed] [Europe PMC] [Abstract]
  11. "Plasminogen activator inhibitor type-1: reactive center and amino-terminal heterogeneity determined by protein and cDNA sequencing."FEBS Lett. 209:213-218(1986) [PubMed] [Europe PMC] [Abstract]
  12. "cDNA cloning and expression in E. coli of a plasminogen activator inhibitor (PAI) related to a PAI produced by Hep G2 hepatoma cell."FEBS Lett. 210:11-16(1987) [PubMed] [Europe PMC] [Abstract]
  13. "Identification of a PAI-1 binding site in vitronectin."Biochim. Biophys. Acta 1208:104-110(1994) [PubMed] [Europe PMC] [Abstract]
  14. "Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene."Blood 90:204-208(1997) [PubMed] [Europe PMC] [Abstract]
  15. "The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein."J. Biol. Chem. 276:28889-28896(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity."Biochem. J. 390:231-242(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Structural basis of latency in plasminogen activator inhibitor-1."Nature 355:270-273(1992) [PubMed] [Europe PMC] [Abstract]
  19. "Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1."Nat. Struct. Biol. 2:891-897(1995) [PubMed] [Europe PMC] [Abstract]
  20. "Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide."Structure 6:627-636(1998) [PubMed] [Europe PMC] [Abstract]
  21. "The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion."Structure 7:111-118(1999) [PubMed] [Europe PMC] [Abstract]
  22. "Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation."J. Mol. Biol. 297:683-695(2000) [PubMed] [Europe PMC] [Abstract]
  23. "Mutational analysis of the genes encoding urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in advanced ovarian cancer."Electrophoresis 18:686-689(1997) [PubMed] [Europe PMC] [Abstract]
  24. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  25. ErratumNat. Genet. 23:373-373(1999)