Cytokeratin 1 (CK1)
[Edit]KRT1; EHK1; K1; KRT1A; KRT1-A; Keratin 1; Epidermolytic Hyperkeratosis; Keratin, type II cytoskeletal 1; 67 kDa cytokeratin; Type-II keratin Kb1
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The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.Keratin 1 is specifically expressed in the spinous and granular layers of the epidermis with family member keratin 10. Mutations in this gene have been associated with the variants of bullous congenital ichthyosiform erythroderma in which the palms and soles of the feet are affected.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA492Hu01 | Recombinant Cytokeratin 1 (CK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA492Hu01 | Polyclonal Antibody to Cytokeratin 1 (CK1) | WB,IHC |
| MAA492Hu22 | Monoclonal Antibody to Cytokeratin 1 (CK1) | WB; IHC; ICC; IP. | |
| LAA492Hu71 | Biotin-Linked Polyclonal Antibody to Cytokeratin 1 (CK1) | WB; IHC; ICC. | |
| Assay Kits | SEA492Hu | ELISA Kit for Cytokeratin 1 (CK1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA492Mu01 | Recombinant Cytokeratin 1 (CK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA492Mu01 | Polyclonal Antibody to Cytokeratin 1 (CK1) | WB; IHC; ICC; IP. |
| LAA492Mu71 | Biotin-Linked Polyclonal Antibody to Cytokeratin 1 (CK1) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for Cytokeratin 1 (CK1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cytokeratin 1 (CK1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA492Ra01 | Recombinant Cytokeratin 1 (CK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA492Ra02 | Recombinant Cytokeratin 1 (CK1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA492Ra01 | Polyclonal Antibody to Cytokeratin 1 (CK1) | WB; IHC; ICC; IP. |
| LAA492Ra71 | Biotin-Linked Polyclonal Antibody to Cytokeratin 1 (CK1) | WB; IHC; ICC. | |
| PAA492Ra02 | Polyclonal Antibody to Cytokeratin 1 (CK1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA492Ra | ELISA Kit for Cytokeratin 1 (CK1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Structure of a gene for the human epidermal 67-kDa keratin."Proc. Natl. Acad. Sci. U.S.A. 82:1896-1900(1985) [PubMed] [Europe PMC] [Abstract]
- "Genomic organization and amplification of the human epidermal type II keratin genes K1 and K5."Biochem. Biophys. Res. Commun. 274:149-152(2000) [PubMed] [Europe PMC] [Abstract]
- "Novel splice site mutation in keratin 1 underlies mild epidermolytic palmoplantar keratoderma in three kindreds."J. Invest. Dermatol. 116:606-609(2001) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]