Endothelin 1 (EDN1)

[Edit]

ET1; PPET1; Preproendothelin-1; Big endothelin-1

Endothelin 1 (EDN1)

Endothelin-1(ET-1), a peptide of 21 amino acid residues, is the most potent vasoconstrictive substance known. Originally isolated from porcine aortic endothelial cells, ET-1 is now known to be one of a family of three mammalian vasoactive peptides that also includes Endothelin-2 (ET-2) and Endothelin-3 (ET-3). These related peptides differ from ET-1 at two and six amino acid residue positions, respectively. A fourth peptide, vasoactive intestinal contractor (VIC), is sometimes classified as rat ET-2. All members of the endothelin family contain two essential disulfide bridges and six conserved amino acid residues at the C-terminus. Additionally, all of the endothelin family members are synthesized initially as prepropolypeptides of approximately 200 amino acid residues encoded by separate genes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA482Hu01 Recombinant Endothelin 1 (EDN1) Positive Control; Immunogen; SDS-PAGE; WB.
CPA482Hu11 BSA Conjugated Endothelin 1 (EDN1) Immunogen; SDS-PAGE; WB.
CPA482Hu21 OVA Conjugated Endothelin 1 (EDN1) Immunogen; SDS-PAGE; WB.
Antibodies PAA482Hu01 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
MAA482Hu22 Monoclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
LAA482Hu72 Biotin-Linked Monoclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC.
LAA482Hu71 Biotin-Linked Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC.
LAA482Hu81 FITC-Linked Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IF.
PAA482Hu08 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
MAA482Hu21 Monoclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
Assay Kits CEA482Hu ELISA Kit for Endothelin 1 (EDN1) Enzyme-linked immunosorbent assay for Antigen Detection.
CCA482Hu CLIA Kit for Endothelin 1 (EDN1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA482Mu01 Recombinant Endothelin 1 (EDN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA482Mu02 Recombinant Endothelin 1 (EDN1) Positive Control; Immunogen; SDS-PAGE; WB.
CPA482Mu11 BSA Conjugated Endothelin 1 (EDN1) Immunogen; SDS-PAGE; WB.
CPA482Mu21 OVA Conjugated Endothelin 1 (EDN1) Immunogen; SDS-PAGE; WB.
Antibodies PAA482Mu01 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
PAA482Mu02 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
PAA482Mu08 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
Assay Kits CEA482Mu ELISA Kit for Endothelin 1 (EDN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA482Ra01 Recombinant Endothelin 1 (EDN1) Positive Control; Immunogen; SDS-PAGE; WB.
CPA482Ra11 BSA Conjugated Endothelin 1 (EDN1) Immunogen; SDS-PAGE; WB.
CPA482Ra21 OVA Conjugated Endothelin 1 (EDN1) Immunogen; SDS-PAGE; WB.
APA482Ra01 Active Endothelin 1 (EDN1) Cell culture; Activity Assays.
Antibodies PAA482Ra01 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
LAA482Ra71 Biotin-Linked Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC.
LAA482Ra81 FITC-Linked Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IF.
MAA482Ra21 Monoclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
PAA482Ra08 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
Assay Kits CEA482Ra ELISA Kit for Endothelin 1 (EDN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA482Gu01 Recombinant Endothelin 1 (EDN1) Positive Control; Immunogen; SDS-PAGE; WB.
CPA482Gu11 BSA Conjugated Endothelin 1 (EDN1) Immunogen; SDS-PAGE; WB.
Antibodies PAA482Gu01 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
MAA482Gu21 Monoclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
PAA482Gu08 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
Assay Kits CEA482Gu ELISA Kit for Endothelin 1 (EDN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA482Rb01 Recombinant Endothelin 1 (EDN1) Positive Control; Immunogen; SDS-PAGE; WB.
CPA482Rb11 BSA Conjugated Endothelin 1 (EDN1) Immunogen; SDS-PAGE; WB.
Antibodies PAA482Rb51 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
MAA482Rb21 Monoclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
Assay Kits CEA482Rb ELISA Kit for Endothelin 1 (EDN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Endothelin 1 (EDN1) Recombinant Protein Customized Service Offer
Antibodies PAA482Si01 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Endothelin 1 (EDN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Endothelin 1 (EDN1) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA482Ca01 Recombinant Endothelin 1 (EDN1) Positive Control; Immunogen; SDS-PAGE; WB.
CPA482Ca11 BSA Conjugated Endothelin 1 (EDN1) Immunogen; SDS-PAGE; WB.
Antibodies PAA482Ca01 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
MAA482Ca21 Monoclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
PAA482Ca08 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
Assay Kits CEA482Ca ELISA Kit for Endothelin 1 (EDN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA482Po01 Recombinant Endothelin 1 (EDN1) Positive Control; Immunogen; SDS-PAGE; WB.
CPA482Po11 BSA Conjugated Endothelin 1 (EDN1) Immunogen; SDS-PAGE; WB.
Antibodies PAA482Po01 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
LAA482Po71 Biotin-Linked Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC.
LAA482Po81 FITC-Linked Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IF.
MAA482Po21 Monoclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
PAA482Po08 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
Assay Kits CEA482Po ELISA Kit for Endothelin 1 (EDN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Endothelin 1 (EDN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Endothelin 1 (EDN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Endothelin 1 (EDN1) Polyclonal Antibody Customized Service Offer
Assay Kits CEA482Cp ELISA Kit for Endothelin 1 (EDN1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin."FEBS Lett. 231:440-444(1988) [PubMed] [Europe PMC] [Abstract]
  2. "The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression."J. Biol. Chem. 264:14954-14959(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Structural organization and chromosomal assignment of the gene encoding endothelin."J. Biol. Chem. 264:10851-10857(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Two preproendothelin 1 mRNAs transcribed by alternative promoters."J. Clin. Invest. 91:1149-1156(1993) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes."Proc. Natl. Acad. Sci. U.S.A. 86:2863-2867(1989) [PubMed] [Europe PMC] [Abstract]
  8. "Proteolytic processing of big endothelin-3 by the kell blood group protein."Blood 94:1440-1450(1999) [PubMed] [Europe PMC] [Abstract]
  9. "The signal peptide of human preproendothelin-1."FEBS Lett. 286:91-94(1991) [PubMed] [Europe PMC] [Abstract]
  10. "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3."J. Clin. Endocrinol. Metab. 82:3116-3123(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol."Am. J. Hum. Genet. 80:673-682(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease."Hum. Genet. 123:307-313(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Crystallization and preliminary X-ray analysis of human endothelin."Acta Crystallogr. B 48:239-240(1992) [PubMed] [Europe PMC] [Abstract]
  14. "The crystal structure of human endothelin."Nat. Struct. Biol. 1:311-319(1994) [PubMed] [Europe PMC] [Abstract]
  15. "The conformation of endothelin-1 in aqueous solution: NMR-derived constraints combined with distance geometry and molecular dynamics calculations."Biochem. Biophys. Res. Commun. 178:570-577(1991) [PubMed] [Europe PMC] [Abstract]
  16. "Conformational isomerism of endothelin in acidic aqueous media: a quantitative NOESY analysis."Biochemistry 31:1280-1295(1992) [PubMed] [Europe PMC] [Abstract]
  17. "Solution conformation of human big endothelin-1."J. Biomol. NMR 2:407-420(1992) [PubMed] [Europe PMC] [Abstract]
  18. "A comparison of X-ray and NMR structures for human endothelin-1."Protein Sci. 4:75-83(1995) [PubMed] [Europe PMC] [Abstract]
  19. "Solution structure of a novel ETB receptor selective agonist ET1-21 [Cys(Acm)1,15, Aib3,11, Leu7] by nuclear magnetic resonance spectroscopy and molecular modelling."J. Pept. Res. 53:223-233(1999) [PubMed] [Europe PMC] [Abstract]
  20. "The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people."Hypertension 33:1169-1174(1999) [PubMed] [Europe PMC] [Abstract]
  21. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
  22. "Mutations in endothelin 1 cause recessive auriculocondylar syndrome and dominant isolated question-mark ears." Am. J. Hum. Genet. 93:1118-1125(2013) [PubMed] [Europe PMC] [Abstract]