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Cardiac Troponin I (cTnI)

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TNNI3; TNNC1; CMH7; C-TnI; Troponin I Type 3; Troponin I Type 3, Cardiac

Cardiac Troponin I (cTnI)
CCC A478
HGNC 11947
MGI 98783
PubMed 8661099
RGD 62052
UniProt P19429
Wiki TNNI3

Troponin I is part of a heteromeric complex playing an important role in the regulation of skeletal and cardiac muscle contraction. It consists of three subunits, troponin I (TnI), troponin T (TnT) and troponin C (TnC). Each subunit is responsible for part of troponin complex function. TnI inhibits ATPase activity of acto myosin and TnT and TnI are present in cardiac muscles in different forms than in skeletal muscles. Only one tissue specific isoform of TnI is described for cardiac muscle tissue (cTnI) and this is expressed only in myocardium.Equally reactive with free cardiac troponin I (cTnI) and cTnI forming complexes with other troponin components. (In the presence of 5 mM EDTA). Antibodies are not affected by heparin, phosphorylation, oxidation and troponin complex formation. No cross-reaction with skeletal muscle troponin I.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA478Hu01 Recombinant Cardiac Troponin I (cTnI) Positive Control; Immunogen; SDS-PAGE; WB.
APA478Hu01 Active Cardiac Troponin I (cTnI) Cell culture; Activity Assays.
RPA478Hu02 Recombinant Cardiac Troponin I (cTnI) Positive Control; Immunogen; SDS-PAGE; WB.
EPA478Hu61 Eukaryotic Cardiac Troponin I (cTnI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA478Hu01 Polyclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
MAA478Hu22 Monoclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
LAA478Hu71 Biotin-Linked Polyclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC.
MAA478Hu21 Monoclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
MAA478Hu23 Monoclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
MAA478Hu24 Monoclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
MAA478Hu25 Monoclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
MAA478Hu27 Monoclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
MAA478Hu29 Monoclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
MAA478Hu28 Monoclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
MAA478Hu26 Monoclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
LAA478Hu74 Biotin-Linked Monoclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC.
Assay Kits SEA478Hu ELISA Kit for Cardiac Troponin I (cTnI) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA478Hu CLIA Kit for Cardiac Troponin I (cTnI) Chemiluminescent immunoassay for Antigen Detection.
HEA478Hu High Sensitive ELISA Kit for Cardiac Troponin I (cTnI) Enzyme-linked immunosorbent assay for Antigen Detection.
AEA478Hu ELISA Kit for Anti-Cardiac Troponin I Antibody (Anti-cTnI) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA478Mu01 Recombinant Cardiac Troponin I (cTnI) Positive Control; Immunogen; SDS-PAGE; WB.
RPA478Mu02 Recombinant Cardiac Troponin I (cTnI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA478Mu01 Polyclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
LAA478Mu71 Biotin-Linked Polyclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC.
LAA478Mu81 FITC-Linked Polyclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IF.
PAA478Mu02 Polyclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
Assay Kits SEA478Mu ELISA Kit for Cardiac Troponin I (cTnI) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA478Ra01 Recombinant Cardiac Troponin I (cTnI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA478Ra01 Polyclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
MAA478Ra21 Monoclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
Assay Kits SEA478Ra ELISA Kit for Cardiac Troponin I (cTnI) Enzyme-linked immunosorbent assay for Antigen Detection.
HEA478Ra High Sensitive ELISA Kit for Cardiac Troponin I (cTnI) Enzyme-linked immunosorbent assay for Antigen Detection.
AEA478Ra ELISA Kit for Anti-Cardiac Troponin I Antibody (Anti-cTnI) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA478Rb01 Recombinant Cardiac Troponin I (cTnI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA478Rb51 Polyclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
PAA478Rb52 Polyclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
Assay Kits SEA478Rb ELISA Kit for Cardiac Troponin I (cTnI) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cardiac Troponin I (cTnI) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cardiac Troponin I (cTnI) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cardiac Troponin I (cTnI) Polyclonal Antibody Customized Service Offer
Assay Kits SEA478Si ELISA Kit for Cardiac Troponin I (cTnI) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA478Ca01 Recombinant Cardiac Troponin I (cTnI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA478Ca01 Polyclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cardiac Troponin I (cTnI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cardiac Troponin I (cTnI) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA478Po01 Recombinant Cardiac Troponin I (cTnI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA478Po01 Polyclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
MAA478Po21 Monoclonal Antibody to Cardiac Troponin I (cTnI) WB; IHC; ICC; IP.
Assay Kits SEA478Po ELISA Kit for Cardiac Troponin I (cTnI) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning of human cardiac troponin I using polymerase chain reaction."FEBS Lett. 270:57-61(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and expression in Escherichia coli of the cDNA encoding human cardiac troponin I."Gene 131:287-292(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Troponin I isoform expression in human heart."Circ. Res. 69:1409-1414(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Isolation and characterization of the human cardiac troponin I gene (TNNI3)."Genomics 35:11-23(1996) [PubMed] [Europe PMC] [Abstract]
  5. "A common motif of two adjacent phosphoserines in bovine, rabbit and human cardiac troponin I."FEBS Lett. 273:41-45(1990) [PubMed] [Europe PMC] [Abstract]
  6. "The ordered phosphorylation of cardiac troponin I by the cAMP-dependent protein kinase -- structural consequences and functional implications."Eur. J. Biochem. 248:329-337(1997) [PubMed] [Europe PMC] [Abstract]
  7. "p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I."Circ. Res. 91:509-516(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function."Circ. Res. 95:1091-1099(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I."Proc. Natl. Acad. Sci. U.S.A. 101:18135-18140(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1."Biochem. J. 418:93-101(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart."Circulation 126:1828-1837(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C."Biochemistry 38:8289-8298(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil."J. Biol. Chem. 277:31124-31133(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy." Nat. Genet. 16:379-382(1997) [PubMed] [Europe PMC] [Abstract]
  15. "Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly."Circulation 105:446-451(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations."J. Clin. Invest. 111:209-216(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy."Circulation 107:2227-2232(2003) [PubMed] [Europe PMC] [Abstract]
  18. ErratumCirculation 109:3258-3258(2004)
  19. "Mutation spectrum in a large cohort of unrelated consecutive patients with hypertrophic cardiomyopathy."Clin. Genet. 64:339-349(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Novel mutation in cardiac troponin I in recessive idiopathic dilated cardiomyopathy."Lancet 363:371-372(2004) [PubMed] [Europe PMC] [Abstract]
  21. "Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling."J. Med. Genet. 42:E59-E59(2005) [PubMed] [Europe PMC] [Abstract]
  22. "Identification and functional characterization of cardiac troponin I as a novel disease gene in autosomal dominant dilated cardiomyopathy."Circ. Res. 105:375-382(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Clinical and mutational spectrum in a cohort of 105 unrelated patients with dilated cardiomyopathy."Eur. J. Med. Genet. 54:E570-E575(2011) [PubMed] [Europe PMC] [Abstract]