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Protein Kinase C Epsilon (PKCe)

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PKC-E; PRKCE; PRKC-E; NPKC-Epsilon

Protein Kinase C Epsilon (PKCe)
CCC A439
HGNC 9401
MGI 97599
PubMed 21347625
RGD 61925
UniProt Q02156
Wiki PRKCE

PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. 

Protein kinase C epsilon type kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA439Hu01 Recombinant Protein Kinase C Epsilon (PKCe) Positive Control; Immunogen; SDS-PAGE; WB.
RPA439Hu02 Recombinant Protein Kinase C Epsilon (PKCe) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA439Hu01 Polyclonal Antibody to Protein Kinase C Epsilon (PKCe) WB; IHC; ICC/IF
MAA439Hu22 Monoclonal Antibody to Protein Kinase C Epsilon (PKCe) WB; IHC; ICC; IP.
LAA439Hu71 Biotin-Linked Polyclonal Antibody to Protein Kinase C Epsilon (PKCe) WB; IHC; ICC.
MAA439Hu21 Monoclonal Antibody to Protein Kinase C Epsilon (PKCe) WB; IHC; ICC; IP.
MAA439Hu23 Monoclonal Antibody to Protein Kinase C Epsilon (PKCe) WB; IHC; ICC; IP.
MAA439Hu24 Monoclonal Antibody to Protein Kinase C Epsilon (PKCe) WB; IHC; ICC; IP.
MAA439Hu25 Monoclonal Antibody to Protein Kinase C Epsilon (PKCe) WB; IHC; ICC; IP.
MAA439Hu27 Monoclonal Antibody to Protein Kinase C Epsilon (PKCe) WB; IHC; ICC; IP.
MAA439Hu29 Monoclonal Antibody to Protein Kinase C Epsilon (PKCe) WB; IHC; ICC; IP.
PAA439Hu02 Polyclonal Antibody to Protein Kinase C Epsilon (PKCe) WB; IHC; ICC; IP.
Assay Kits SEA439Hu ELISA Kit for Protein Kinase C Epsilon (PKCe) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA439Hu CLIA Kit for Protein Kinase C Epsilon (PKCe) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA439Mu01 Recombinant Protein Kinase C Epsilon (PKCe) Positive Control; Immunogen; SDS-PAGE; WB.
RPA439Mu02 Recombinant Protein Kinase C Epsilon (PKCe) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA439Mu01 Polyclonal Antibody to Protein Kinase C Epsilon (PKCe) WB; IHC; ICC; IP.
PAA439Mu02 Polyclonal Antibody to Protein Kinase C Epsilon (PKCe) WB; IHC; ICC; IP.
Assay Kits SEA439Mu ELISA Kit for Protein Kinase C Epsilon (PKCe) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA439Ra01 Recombinant Protein Kinase C Epsilon (PKCe) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA439Ra01 Polyclonal Antibody to Protein Kinase C Epsilon (PKCe) WB; IHC; ICC; IP.
MAA439Ra21 Monoclonal Antibody to Protein Kinase C Epsilon (PKCe) WB; IHC; ICC; IP.
Assay Kits SEA439Ra ELISA Kit for Protein Kinase C Epsilon (PKCe) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18."J. Cell Biol. 117:583-593(1992) [PubMed] [Europe PMC] [Abstract]
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  7. "Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator."J. Biol. Chem. 279:48495-48504(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C."J. Biol. Chem. 280:9870-9878(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Trif-related adapter molecule is phosphorylated by PKCepsilon during Toll-like receptor 4 signaling."Proc. Natl. Acad. Sci. U.S.A. 103:9196-9201(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer."Cancer Res. 67:8828-8838(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Protein kinase C alpha and epsilon differentially modulate hepatocyte growth factor-induced epithelial proliferation and migration."Exp. Eye Res. 85:289-297(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits."J. Biol. Chem. 282:33052-33063(2007) [PubMed] [Europe PMC] [Abstract]
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  14. "TNF-related apoptosis-inducing ligand (TRAIL) and erythropoiesis: a role for PKC epsilon."Eur. J. Histochem. 50:15-18(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Protein kinase Cepsilon: function in neurons."FEBS J. 275:3988-3994(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Protein kinase Cepsilon: multiple roles in the function of, and signaling mediated by, the cytoskeleton."FEBS J. 275:3995-4004(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  18. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  19. "The substrates and binding partners of protein kinase Cepsilon."Biochem. J. 427:189-196(2010) [PubMed] [Europe PMC] [Abstract]
  20. "The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases."Front. Med. 5:70-76(2011) [PubMed] [Europe PMC] [Abstract]
  21. "PKC-delta and PKC-epsilon: Foes of the same family or strangers?"J. Mol. Cell. Cardiol. 51:665-673(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon."EMBO Rep. 10:983-989(2009) [PubMed] [Europe PMC] [Abstract]
  23. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  24. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]