Sex Determining Region Y Box Protein 18 (SOX18)

[Edit]

HLTS; SRY-Box 18

Sex Determining Region Y Box Protein 18 (SOX18)

Transcription factor SOX-18 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Greenfield et al. (1996) described a novel member of the mouse Sox gene family, Sox18, which is transcribed in adult lung and in cardiac and skeletal muscle. They reported that the Sox18 protein binds the sequence AACAAAG in vitro and that it is capable of transactivating gene expression. Pennisi et al. (2000) found that Sox18 is expressed in the developing vascular endothelium and hair follicles in mouse embryos.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA414Hu01 Recombinant Sex Determining Region Y Box Protein 18 (SOX18) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA414Hu01 Polyclonal Antibody to Sex Determining Region Y Box Protein 18 (SOX18) WB; IHC; ICC; IP.
MAA414Hu22 Monoclonal Antibody to Sex Determining Region Y Box Protein 18 (SOX18) WB; IHC; ICC; IP.
Assay Kits SEA414Hu ELISA Kit for Sex Determining Region Y Box Protein 18 (SOX18) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sex Determining Region Y Box Protein 18 (SOX18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sex Determining Region Y Box Protein 18 (SOX18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sex Determining Region Y Box Protein 18 (SOX18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sex Determining Region Y Box Protein 18 (SOX18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sex Determining Region Y Box Protein 18 (SOX18) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA414Ra01 Recombinant Sex Determining Region Y Box Protein 18 (SOX18) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA414Ra01 Polyclonal Antibody to Sex Determining Region Y Box Protein 18 (SOX18) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Sex Determining Region Y Box Protein 18 (SOX18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sex Determining Region Y Box Protein 18 (SOX18) ELISA Kit Customized Service Offer
  1. "The human SOX18 gene: cDNA cloning and high resolution mapping."Biochim. Biophys. Acta 1492:237-241(2000) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning, tissue expression, and chromosome mapping of human homolog of SOX18."J. Hum. Genet. 45:192-195(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Structure, mapping, and expression of human SOX18."Mamm. Genome 11:1147-1149(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A conserved family of genes related to the testis determining gene, SRY."Nucleic Acids Res. 20:2887-2887(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in the transcription factor gene SOX18 underlie recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia."Am. J. Hum. Genet. 72:1470-1478(2003) [PubMed] [Europe PMC] [Abstract]