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Phospholipase A2, Calcium Independent (iPLA2)

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PLA2G6; CaI-PLA2; GVI; INAD1; PNPLA9; Ca2+ Independent PLA2; 85 kDa Calcium-Independent Phospholipase A2; Phospholipase A2,group VI(Cytosolic,Calcium-Independent)

Phospholipase A2, Calcium Independent (iPLA2)
CCC A411
HGNC 9039
MGI 1859152
PubMed 18936091
RGD 628867
UniProt O60733
Wiki PLA2G6

85 kDa calcium-independent phospholipase A2 is is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only two of them have been determined to date.Tang et al. (1997) purified an 85-kD cytosolic calcium-independent PLA2, termed iPLA2, from Chinese hamster ovary (CHO) cells. They isolated a partial human cDNA from a Burkitt lymphoma cDNA library by screening with a CHO cDNA. Northern blot analysis revealed that iPLA2 is expressed in a variety of rodent tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA411Hu01 Recombinant Phospholipase A2, Calcium Independent (iPLA2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA411Hu01 Polyclonal Antibody to Phospholipase A2, Calcium Independent (iPLA2) WB; ICC; IHC-P; IHC-F; ELISA.
MAA411Hu22 Monoclonal Antibody to Phospholipase A2, Calcium Independent (iPLA2) WB; IHC; ICC; IP.
Assay Kits SEA411Hu ELISA Kit for Phospholipase A2, Calcium Independent (iPLA2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA411Mu01 Recombinant Phospholipase A2, Calcium Independent (iPLA2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA411Mu01 Polyclonal Antibody to Phospholipase A2, Calcium Independent (iPLA2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Phospholipase A2, Calcium Independent (iPLA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase A2, Calcium Independent (iPLA2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA411Ra01 Recombinant Phospholipase A2, Calcium Independent (iPLA2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA411Ra01 Polyclonal Antibody to Phospholipase A2, Calcium Independent (iPLA2) WB; IHC; ICC; IP.
MAA411Ra21 Monoclonal Antibody to Phospholipase A2, Calcium Independent (iPLA2) WB; IHC; ICC; IP.
Assay Kits SEA411Ra ELISA Kit for Phospholipase A2, Calcium Independent (iPLA2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity."J. Biol. Chem. 273:207-214(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1."J. Biol. Chem. 274:9607-9616(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The human calcium-independent phospholipase A2 gene. Multiple enzymes with distinct properties from a single gene."Eur. J. Biochem. 262:575-585(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "iPLA2beta: front and center in human monocyte chemotaxis to MCP-1."J. Exp. Med. 205:347-359(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions."J. Lipid Res. 50:S63-S68(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome."Proc. Natl. Acad. Sci. U.S.A. 106:2337-2341(2009) [PubMed] [Europe PMC] [Abstract]
  12. "PLA2G6 mutation underlies infantile neuroaxonal dystrophy."Am. J. Hum. Genet. 79:942-948(2006) [PubMed] [Europe PMC] [Abstract]
  13. "PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron." Nat. Genet. 38:752-754(2006) [PubMed] [Europe PMC] [Abstract]
  14. Erratum Nat. Genet. 38:957-957(2006)
  15. "Characterization of PLA2G6 as a locus for dystonia-parkinsonism."Ann. Neurol. 65:19-23(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Recessive truncating NALCN mutation in infantile neuroaxonal dystrophy with facial dysmorphism."J. Med. Genet. 50:515-520(2013) [PubMed] [Europe PMC] [Abstract]