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Cadherin, Retinal (RCAD)

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CDH4; CAD4; R-CAD; Cadherin 4 Type 1; R-Cadherin

Cadherin, Retinal (RCAD)
CCC A409
HGNC 1763
MGI 99218
PubMed 19491271
RGD 1586170
UniProt P55283
Wiki CDH4

Cadherin-4 is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth.

In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA409Hu01 Recombinant Cadherin, Retinal (RCAD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA409Hu01 Polyclonal Antibody to Cadherin, Retinal (RCAD) WB; IHC; ICC; IP.
LAA409Hu81 FITC-Linked Polyclonal Antibody to Cadherin, Retinal (RCAD) WB; IHC; ICC; IF.
LAA409Hu71 Biotin-Linked Polyclonal Antibody to Cadherin, Retinal (RCAD) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Cadherin, Retinal (RCAD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cadherin, Retinal (RCAD) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cadherin, Retinal (RCAD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cadherin, Retinal (RCAD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cadherin, Retinal (RCAD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cadherin, Retinal (RCAD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cadherin, Retinal (RCAD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cadherin, Retinal (RCAD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cadherin, Retinal (RCAD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cadherin, Retinal (RCAD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cadherin, Retinal (RCAD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cadherin, Retinal (RCAD) ELISA Kit Customized Service Offer
  1. "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin."Cell Adhes. Commun. 2:15-26(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue."Cell Regul. 2:261-270(1991) [PubMed] [Europe PMC] [Abstract]