Sex Determining Region Y Box Protein 3 (SOX3)

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MRGH; SOXB; PHP; SRY-Box 3; Panhypopituitarism; Transcription factor SOX-3

Sex Determining Region Y Box Protein 3 (SOX3)

Stevanovic et al. (1993) cloned and characterized SOX3. A reverse transcription coupled with PCR (RT-PCR) was used to amplify SRY-related transcripts expressed during embryogenesis in human fetal spinal cord. Inspection of fragments detected by one of them showed a difference between males and females, suggesting a SOX gene located on the X chromosome. Isolation and sequencing of the gene showed 97.2% similarity to the protein encoded by the mouse Sox3 gene which is also located on the X chromosome. The RACE (rapid amplification of complementary DNA ends) method was used to define the 3-prime end of the transcript and to confirm that the SOX3 gene is expressed. Using the sensitive RT-PCR assay, SOX3 gene transcripts were detected in several fetal tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sex Determining Region Y Box Protein 3 (SOX3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sex Determining Region Y Box Protein 3 (SOX3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sex Determining Region Y Box Protein 3 (SOX3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sex Determining Region Y Box Protein 3 (SOX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sex Determining Region Y Box Protein 3 (SOX3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sex Determining Region Y Box Protein 3 (SOX3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sex Determining Region Y Box Protein 3 (SOX3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sex Determining Region Y Box Protein 3 (SOX3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sex Determining Region Y Box Protein 3 (SOX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sex Determining Region Y Box Protein 3 (SOX3) ELISA Kit Customized Service Offer
  1. "SOX3 is an X-linked gene related to SRY."Hum. Mol. Genet. 2:2013-2018(1993) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A conserved family of genes related to the testis determining gene, SRY."Nucleic Acids Res. 20:2887-2887(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of SOX3 as an XX male sex reversal gene in mice and humans." J. Clin. Invest. 121:328-341(2011) [PubMed] [Europe PMC] [Abstract]
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Transcription factor SOX3 is involved in X-linked mental retardation with growth hormone deficiency."Am. J. Hum. Genet. 71:1450-1455(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Over- and underdosage of SOX3 is associated with infundibular hypoplasia and hypopituitarism."Am. J. Hum. Genet. 76:833-849(2005) [PubMed] [Europe PMC] [Abstract]