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Tachykinin Receptor 1 (TACR1)

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NK1R; SPR; NKIR; TAC1R; Neurokinin 1 Receptor; Substance P Receptor

Tachykinin Receptor 1 (TACR1)
CCC A392
HGNC 11526
MGI 98475
PubMed 23419547
RGD 3811
UniProt P25103
Wiki TACR1

The tachykinin receptor 1 (TACR1) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene.Fong et al. (1992) cloned a splice variant of human NK1R that encodes a 311-amino acid protein with a truncated C terminus.

This receptor is considered an attractive drug target, particularly with regards to potential analgesics and anti-depressants. It was identified as a candidate in the etiology of bipolar disorder by a 2008 study. Furthermore TACR1 antagonists have shown promise for the treatment in alcoholism. Finally TACR1 antagonists may also have a role as novel antiemetics.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA392Hu01 Recombinant Tachykinin Receptor 1 (TACR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA392Hu01 Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IP.
MAA392Hu22 Monoclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IP.
Assay Kits SEA392Hu ELISA Kit for Tachykinin Receptor 1 (TACR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tachykinin Receptor 1 (TACR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tachykinin Receptor 1 (TACR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tachykinin Receptor 1 (TACR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tachykinin Receptor 1 (TACR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tachykinin Receptor 1 (TACR1) Recombinant Protein Customized Service Offer
Antibodies PAA392Ra01 Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IP.
Assay Kits SEA392Ra ELISA Kit for Tachykinin Receptor 1 (TACR1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning, structural characterization and functional expression of the human substance P receptor."Biochem. Biophys. Res. Commun. 179:1232-1240(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and characterisation of the human lung NK-1 receptor cDNA."Biochem. Biophys. Res. Commun. 180:1110-1117(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones."Biochemistry 30:10640-10646(1991) [PubMed] [Europe PMC] [Abstract]
  4. "The primary structure and gene organization of human substance P and neuromedin K receptors."Eur. J. Biochem. 204:1025-1033(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor."Mol. Pharmacol. 41:24-30(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The human tachykinin NK1 (short form) and tachykinin NK4 receptor: a reappraisal."Eur. J. Pharmacol. 437:27-30(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345."Nature 362:350-353(1993) [PubMed] [Europe PMC] [Abstract]
  11. "NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles."Biochim. Biophys. Acta 1808:127-139(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of single-nucleotide polymorphisms of the human neurokinin 1 receptor gene and pharmacological characterization of a Y192H variant."Pharmacogenomics J. 4:394-402(2004) [PubMed] [Europe PMC] [Abstract]