Follistatin (FS)

Follistatin was first identified as a follicle-stimulating hormone inhibiting substance present in ovarian follicular fluid. It has since been shown to be a multifunctional regulatory protein exerting a majority of its effects via neutralization of activin. FS is a monomeric binding protein that regulates activin activity by forming an inactive complex. FS plays a role as a tissue regulator in the gonad, pituitary gland,pregnancy membranes, vasculature, and liver. It is also essential for normal development, as FS-knockout mice die shortly after birth with a range of defects including insufficient muscle development and skeletal abnormalities. Alternative splicing events, proteolytic cleavage and variable glycosylation lead to a vast array of possible FS isoforms found within various biological fluids.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA391Hu01 Recombinant Follistatin (FS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA391Hu01 Polyclonal Antibody to Follistatin (FS) WB; IHC; ICC; IP.
MAA391Hu22 Monoclonal Antibody to Follistatin (FS) WB; IHC; ICC; IP.
Assay Kits SEA391Hu ELISA Kit for Follistatin (FS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA391Mu01 Recombinant Follistatin (FS) Positive Control; Immunogen; SDS-PAGE; WB.
RPA391Mu02 Recombinant Follistatin (FS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA391Mu01 Polyclonal Antibody to Follistatin (FS) WB; IHC; ICC; IP.
PAA391Mu02 Polyclonal Antibody to Follistatin (FS) WB; IHC; ICC; IP.
Assay Kits CEA391Mu ELISA Kit for Follistatin (FS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA391Ra01 Recombinant Follistatin (FS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA391Ra01 Polyclonal Antibody to Follistatin (FS) WB; IHC; ICC; IP.
MAA391Ra21 Monoclonal Antibody to Follistatin (FS) WB; IHC; ICC; IP.
Assay Kits CEA391Ra ELISA Kit for Follistatin (FS) Enzyme-linked immunosorbent assay for Antigen Detection.
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  6. "The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding."Dev. Cell 9:535-543(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions."J. Biol. Chem. 282:15930-15939(2007) [PubMed] [Europe PMC] [Abstract]
  8. "The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding."EMBO J. 28:2662-2676(2009) [PubMed] [Europe PMC] [Abstract]