≡

Actinin Alpha 2 (ACTN2)

[Edit]

Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein

Actinin Alpha 2 (ACTN2)
CCC A376
HGNC 164
MGI 109192
PubMed 10548523
RGD 1308097
UniProt P35609
Wiki ACTN2

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins.

Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. Studies have also implicated alpha actinin in the binding of cardiac ion channels, Kv1.5 in particular.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA376Hu01 Recombinant Actinin Alpha 2 (ACTN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA376Hu01 Polyclonal Antibody to Actinin Alpha 2 (ACTN2) WB; IHC; ICC; IP.
MAA376Hu22 Monoclonal Antibody to Actinin Alpha 2 (ACTN2) WB; IHC; ICC; IP.
Assay Kits SEA376Hu ELISA Kit for Actinin Alpha 2 (ACTN2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA376Mu01 Recombinant Actinin Alpha 2 (ACTN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA376Mu01 Polyclonal Antibody to Actinin Alpha 2 (ACTN2) WB,IHC
LAA376Mu71 Biotin-Linked Polyclonal Antibody to Actinin Alpha 2 (ACTN2) WB; IHC; ICC.
LAA376Mu81 FITC-Linked Polyclonal Antibody to Actinin Alpha 2 (ACTN2) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Actinin Alpha 2 (ACTN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actinin Alpha 2 (ACTN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Actinin Alpha 2 (ACTN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Actinin Alpha 2 (ACTN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Actinin Alpha 2 (ACTN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Actinin Alpha 2 (ACTN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actinin Alpha 2 (ACTN2) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11."J. Biol. Chem. 267:9281-9288(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Fine mapping and genomic structure of ACTN2, the human gene coding for the sarcomeric isoform of alpha-actinin-2, expressed in skeletal and cardiac muscle."Biochem. Biophys. Res. Commun. 265:256-259(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "ZASP: a new Z-band alternatively spliced PDZ-motif protein."J. Cell Biol. 146:465-475(1999) [PubMed] [Europe PMC] [Abstract]
  7. "FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle."J. Biol. Chem. 275:41234-41242(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins."Proc. Natl. Acad. Sci. U.S.A. 97:14632-14637(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines."Proc. Natl. Acad. Sci. U.S.A. 98:1595-1600(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins."J. Biol. Chem. 277:13998-14004(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction."J. Cell Biol. 165:539-551(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein."J. Biol. Chem. 281:39370-39379(2006) [PubMed] [Europe PMC] [Abstract]
  13. "BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin."Exp. Cell Res. 316:297-313(2010) [PubMed] [Europe PMC] [Abstract]
  14. "F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo."Circ. Res. 111:1504-1516(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Structure of the alpha-actinin rod: molecular basis for cross-linking of actin filaments."Cell 98:537-546(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Ca2+-independent binding of an EF-hand domain to a novel motif in the alpha-actinin-titin complex."Nat. Struct. Biol. 8:853-857(2001) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structure of the alpha-actinin rod reveals an extensive torsional twist."Structure 9:597-604(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Mutations in the muscle LIM protein and alpha-actinin-2 genes in dilated cardiomyopathy and endocardial fibroelastosis."Mol. Genet. Metab. 80:207-215(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Mutations in alpha-actinin-2 cause hypertrophic cardiomyopathy: a genome-wide analysis."J. Am. Coll. Cardiol. 55:1127-1135(2010) [PubMed] [Europe PMC] [Abstract]