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GATA Binding Protein 4 (GATA4)

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Transcription factor GATA-4

GATA Binding Protein 4 (GATA4)
CCC A374
HGNC 4173
MGI 95664
PubMed 23132827
RGD 2665
UniProt P43694
Wiki GATA4

Transcription factor GATA-4 is a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.A fourth member of the GATA-binding family, GATA4, is expressed in adult vertebrate heart, gut epithelium, and gonads. During fetal development, GATA4 is expressed in yolk sac endoderm and cells involved in heart formation. This factor may regulate genes critical for myocardial differentiation and function, including troponin C , cardiac alpha-myosin heavy chain (MYH6), and brain-type natriuretic factor .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA374Hu01 Recombinant GATA Binding Protein 4 (GATA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA374Hu01 Polyclonal Antibody to GATA Binding Protein 4 (GATA4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for GATA Binding Protein 4 (GATA4) CLIA Kit Customized Service Offer
n/a ELISA Kit for GATA Binding Protein 4 (GATA4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GATA Binding Protein 4 (GATA4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GATA Binding Protein 4 (GATA4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GATA Binding Protein 4 (GATA4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GATA Binding Protein 4 (GATA4) CLIA Kit Customized Service Offer
n/a ELISA Kit for GATA Binding Protein 4 (GATA4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA374Ra01 Recombinant GATA Binding Protein 4 (GATA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA374Ra01 Polyclonal Antibody to GATA Binding Protein 4 (GATA4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for GATA Binding Protein 4 (GATA4) CLIA Kit Customized Service Offer
n/a ELISA Kit for GATA Binding Protein 4 (GATA4) ELISA Kit Customized Service Offer
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  2. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes."J. Biol. Chem. 285:9556-9568(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Loss-of-function mutation in GATA4 causes anomalies of human testicular development."Proc. Natl. Acad. Sci. U.S.A. 108:1597-1602(2011) [PubMed] [Europe PMC] [Abstract]
  7. "GATA4 loss-of-function mutation underlies familial dilated cardiomyopathy."Biochem. Biophys. Res. Commun. 439:591-596(2013) [PubMed] [Europe PMC] [Abstract]
  8. "GATA4 loss-of-function mutations underlie familial tetralogy of fallot."Hum. Mutat. 34:1662-1671(2013) [PubMed] [Europe PMC] [Abstract]
  9. "Prevalence and spectrum of GATA4 mutations associated with sporadic dilated cardiomyopathy."Gene 548:174-181(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Solution NMR structure of a transcription factor gata-4 from Homo sapiens, Northeast structural genomics consortium (NESG) target HR4783B."Submitted (JUL-2013) to the PDB data bank
  11. "GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5."Nature 424:443-447(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Phenotypes with GATA4 or NKX2.5 mutations in familial atrial septal defect."Am. J. Med. Genet. A 135:47-52(2005) [PubMed] [Europe PMC] [Abstract]
  13. "GATA4 sequence variants in patients with congenital heart disease."J. Med. Genet. 44:779-783(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Spectrum of heart disease associated with murine and human GATA4 mutation."J. Mol. Cell. Cardiol. 43:677-685(2007) [PubMed] [Europe PMC] [Abstract]
  15. "GATA4 mutations in 486 Chinese patients with congenital heart disease."Eur. J. Med. Genet. 51:527-535(2008) [PubMed] [Europe PMC] [Abstract]
  16. "A novel mutation of GATA4 in a familial atrial septal defect."Clin. Chim. Acta 411:1741-1745(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Mutations of the GATA4 and NKX2.5 genes in Chinese pediatric patients with non-familial congenital heart disease."Genetica 138:1231-1240(2010) [PubMed] [Europe PMC] [Abstract]
  18. "A novel mutation in GATA4 gene associated with dominant inherited familial atrial septal defect."J. Thorac. Cardiovasc. Surg. 140:684-687(2010) [PubMed] [Europe PMC] [Abstract]
  19. "A novel GATA4 mutation responsible for congenital ventricular septal defects."Int. J. Mol. Med. 28:557-564(2011) [PubMed] [Europe PMC] [Abstract]
  20. "A novel GATA4 loss-of-function mutation associated with congenital ventricular septal defect."Pediatr. Cardiol. 33:539-546(2012) [PubMed] [Europe PMC] [Abstract]