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Chromodomain Helicase DNA Binding Protein 3 (CHD3)

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Mi-2a; Mi2-ALPHA; ZFH; ATP-dependent helicase CHD3; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Zinc finger helicase

Chromodomain Helicase DNA Binding Protein 3 (CHD3)
CCC A317
HGNC 1918
MGI 1344395
PubMed 22451926
RGD 1311923
UniProt Q12873
Wiki CHD3

Chromodomain-helicase-DNA-binding protein 3 is a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains.

This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription.

Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA317Hu01 Recombinant Chromodomain Helicase DNA Binding Protein 3 (CHD3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA317Hu01 Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits n/a CLIA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA317Mu01 Recombinant Chromodomain Helicase DNA Binding Protein 3 (CHD3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA317Mu01 Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromodomain Helicase DNA Binding Protein 3 (CHD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) ELISA Kit Customized Service Offer
  1. "Identification of a human 17p-located cDNA encoding a protein of the Snf2-like helicase family."Eur. J. Biochem. 254:558-564(1998) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the CHD family of proteins."Proc. Natl. Acad. Sci. U.S.A. 94:11472-11477(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular analysis of a major antigenic region of the 240 kD protein of Mi-2 autoantigen."J. Clin. Invest. 96:1730-1737(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex."Nature 395:917-921(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD."Genes Dev. 15:428-443(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3."FEBS Lett. 533:14-20(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity."Mol. Biol. Cell 18:3667-3680(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]