Connexin 43 (CX43)

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ODDD; GJAL; GJA1; GJ-A1; Gap junction 43 kDa heart protein; Gap Junction Protein Alpha 1; Oculodentodigital Dysplasia; Syndactyly Type III

Connexin 43 (CX43)

Connexin 43 is a connexin gap junction found in several organs and cell types, but is most often found in the heart. Current data suggest Cx43 is essential for the development of normal cardiac architecture and ventricular conduction. Two members of the connexin gene family, connexins 43 and 32, or GJB1, are abundantly expressed in the heart and liver, respectively. GAP43-like immunoreactivity in rat is mainly present in sympathetic and sensory nerve fibers as well as in perivascular nerve terminals. This peptide is axonally transported predominantly in sensory and adrenergic axonsSohl et al. (2003) stated that the mouse and human CX43 share 97% amino acid identity. Northern blot analysis detected variable expression of a 3.0-kb CX43 transcript in both mouse and human, with highest expression in heart.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA277Hu01 Recombinant Connexin 43 (CX43) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA277Hu01 Polyclonal Antibody to Connexin 43 (CX43) WB; IHC; ICC; IP.
MAA277Hu22 Monoclonal Antibody to Connexin 43 (CX43) WB; IHC; ICC; IP.
Assay Kits SEA277Hu ELISA Kit for Connexin 43 (CX43) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA277Mu01 Recombinant Connexin 43 (CX43) Positive Control; Immunogen; SDS-PAGE; WB.
RPA277Mu02 Recombinant Connexin 43 (CX43) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA277Mu01 Polyclonal Antibody to Connexin 43 (CX43) WB; IHC; ICC; IP.
PAA277Mu02 Polyclonal Antibody to Connexin 43 (CX43) WB; IHC; ICC; IP.
Assay Kits SEA277Mu ELISA Kit for Connexin 43 (CX43) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA277Ra01 Recombinant Connexin 43 (CX43) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA277Ra01 Polyclonal Antibody to Connexin 43 (CX43) WB; IHC; ICC; IP.
MAA277Ra21 Monoclonal Antibody to Connexin 43 (CX43) WB; IHC; ICC; IP.
Assay Kits SEA277Ra ELISA Kit for Connexin 43 (CX43) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA277Rb01 Recombinant Connexin 43 (CX43) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA277Rb51 Polyclonal Antibody to Connexin 43 (CX43) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Connexin 43 (CX43) CLIA Kit Customized Service Offer
n/a ELISA Kit for Connexin 43 (CX43) ELISA Kit Customized Service Offer

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA277Si01 Recombinant Connexin 43 (CX43) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA277Si01 Polyclonal Antibody to Connexin 43 (CX43) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Connexin 43 (CX43) CLIA Kit Customized Service Offer
n/a ELISA Kit for Connexin 43 (CX43) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA277Ca01 Recombinant Connexin 43 (CX43) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA277Ca01 Polyclonal Antibody to Connexin 43 (CX43) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Connexin 43 (CX43) CLIA Kit Customized Service Offer
n/a ELISA Kit for Connexin 43 (CX43) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA277Po01 Recombinant Connexin 43 (CX43) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA277Po01 Polyclonal Antibody to Connexin 43 (CX43) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Connexin 43 (CX43) CLIA Kit Customized Service Offer
n/a ELISA Kit for Connexin 43 (CX43) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA277Bo01 Recombinant Connexin 43 (CX43) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA277Bo01 Polyclonal Antibody to Connexin 43 (CX43) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Connexin 43 (CX43) CLIA Kit Customized Service Offer
n/a ELISA Kit for Connexin 43 (CX43) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA277Ga01 Recombinant Connexin 43 (CX43) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA277Ga01 Polyclonal Antibody to Connexin 43 (CX43) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Connexin 43 (CX43) CLIA Kit Customized Service Offer
n/a ELISA Kit for Connexin 43 (CX43) ELISA Kit Customized Service Offer
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  34. "Oculodentodigital dysplasia with mandibular retrognathism and absence of syndactyly: a case report with a novel mutation in the connexin 43 gene."Int. J. Oral Maxillofac. Surg. 36:858-860(2007) [PubMed] [Europe PMC] [Abstract]
  35. "A new GJA1 (connexin 43) mutation causing oculodentodigital dysplasia associated to uncommon features."Ophthalmic Genet. 28:198-202(2007) [PubMed] [Europe PMC] [Abstract]
  36. "GJA1 mutations, variants, and connexin 43 dysfunction as it relates to the oculodentodigital dysplasia phenotype."Hum. Mutat. 30:724-733(2009) [PubMed] [Europe PMC] [Abstract]
  37. "Oculodentodigital dysplasia: new ocular findings and a novel connexin 43 mutation."Arch. Ophthalmol. 129:781-784(2011) [PubMed] [Europe PMC] [Abstract]
  38. "A novel mutation in GJA1 causing oculodentodigital syndrome and primary lymphoedema in a three generation family."Clin. Genet. 84:378-381(2013) [PubMed] [Europe PMC] [Abstract]
  39. "A novel autosomal recessive GJA1 missense mutation linked to Craniometaphyseal dysplasia."PLoS ONE 8:E73576-E73576(2013) [PubMed] [Europe PMC] [Abstract]
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