≡

Immunoglobulin superfamily, member 1 (IGSF1)

[Edit]

INHBP; IGCD1; IGDC1; INHBP; PGSF2; p120; Immunoglobulin Superfamily Member 1; Immunoglobulin-like domain-containing protein 1; Pituitary gland-specific factor 2

Immunoglobulin superfamily, member 1 (IGSF1)
CCC A273
HGNC 5948
MGI 2147913
PubMed 12832474
RGD 631402
UniProt Q8N6C5
Wiki IGSF1

IGSF1 contained 12 Ig-like domains of the C2 (constant region type 2) type. In addition, IGSF1 has a signal sequence and a potential transmembrane domain. IGSF1 was expressed as a 4.7-kb mRNA in many of the tissues tested, with the highest expression in pancreas, testis, and fetal liver. Additional 2.8- and 5.5-kb transcripts were observed in heart and testis, respectively. The cDNAs encoded a predicted 1,327-amino acid protein that was designated 'immunoglobulin superfamily member-1' (IGSF1) because it contained 12 Ig-like domains of the C2 (constant region type 2) type. In addition, IGSF1 has a signal sequence and a potential transmembrane domain. Northern blot analysis revealed that IGSF1 was expressed as a 4.7-kb mRNA in many of the tissues tested, with the highest expression in pancreas, testis, and fetal liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA273Hu01 Recombinant Immunoglobulin superfamily, member 1 (IGSF1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA273Hu03 Recombinant Immunoglobulin superfamily, member 1 (IGSF1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA273Hu02 Recombinant Immunoglobulin superfamily, member 1 (IGSF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA273Hu01 Polyclonal Antibody to Immunoglobulin superfamily, member 1 (IGSF1) WB; IHC; ICC; IP.
MAA273Hu22 Monoclonal Antibody to Immunoglobulin superfamily, member 1 (IGSF1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Immunoglobulin superfamily, member 1 (IGSF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin superfamily, member 1 (IGSF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA273Mu01 Recombinant Immunoglobulin superfamily, member 1 (IGSF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA273Mu01 Polyclonal Antibody to Immunoglobulin superfamily, member 1 (IGSF1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Immunoglobulin superfamily, member 1 (IGSF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin superfamily, member 1 (IGSF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA273Ra01 Recombinant Immunoglobulin superfamily, member 1 (IGSF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA273Ra01 Polyclonal Antibody to Immunoglobulin superfamily, member 1 (IGSF1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Immunoglobulin superfamily, member 1 (IGSF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin superfamily, member 1 (IGSF1) ELISA Kit Customized Service Offer
  1. "Identification and genomic organization of a gene coding for a new member of the cell adhesion molecule family mapping to Xq25."Gene 214:1-6(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and expression of an immunoglobulin superfamily gene (IGSF1) in Xq25."Genomics 48:157-162(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Expression profile of active genes in the human pituitary gland."J. Mol. Endocrinol. 28:33-44(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP)."Mol. Endocrinol. 15:668-679(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs."Genome Res. 12:1773-1784(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors."Mol. Cell. Endocrinol. 196:79-93(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement." Nat. Genet. 44:1375-1381(2012) [PubMed] [Europe PMC] [Abstract]