Paraoxonase 1 (PON1)

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ESA; PON; Esterase A; Serum paraoxonase/arylesterase 1; Aromatic esterase 1; A-esterase 1; Serum aryldialkylphosphatase 1

Paraoxonase 1 (PON1)

The paraoxonase (PON) gene family includes 3 genes, PON1, PON2, and PON3, aligned next to each other on chromosome 7. PON1 (EC 3.1.1.2) hydrolyzes the toxic oxon metabolites of several organophosphorous insecticides, including parathion, diazinon, and chlorpyrifos, as well as nerve agents, such as sarin and soman. PON1 also hydrolyzes aromatic esters, preferably those of acetic acid. In addition, PON1 hydrolyzes a variety of aromatic and aliphatic lactones, and it also catalyzes the reverse reaction, lactonization, of gamma- and delta-hydroxycarboxylic acids. Human PON1 is synthesized in liver and secreted into blood, where it is associated exclusively with high density lipoproteins (HDLs) and may protect against development of atherosclerosis (Draganov et al., 2005).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA243Hu01 Recombinant Paraoxonase 1 (PON1) Positive Control; Immunogen; SDS-PAGE; WB.
APA243Hu01 Active Paraoxonase 1 (PON1) Cell culture; Activity Assays.
RPA243Hu02 Recombinant Paraoxonase 1 (PON1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA243Hu03 Recombinant Paraoxonase 1 (PON1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA243Hu04 Recombinant Paraoxonase 1 (PON1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA243Hu05 Recombinant Paraoxonase 1 (PON1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA243Hu01 Polyclonal Antibody to Paraoxonase 1 (PON1) WB; IHC; ICC; IP.
MAA243Hu22 Monoclonal Antibody to Paraoxonase 1 (PON1) WB; IHC; ICC; IP.
LAA243Hu71 Biotin-Linked Polyclonal Antibody to Paraoxonase 1 (PON1) WB; IHC; ICC.
LAA243Hu81 FITC-Linked Polyclonal Antibody to Paraoxonase 1 (PON1) WB; IHC; ICC; IF.
PAA243Hu02 Polyclonal Antibody to Paraoxonase 1 (PON1) WB; IHC; ICC; IP.
Assay Kits SEA243Hu ELISA Kit for Paraoxonase 1 (PON1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA243Hu CLIA Kit for Paraoxonase 1 (PON1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA243Mu01 Recombinant Paraoxonase 1 (PON1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA243Mu02 Recombinant Paraoxonase 1 (PON1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA243Mu61 Eukaryotic Paraoxonase 1 (PON1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA243Mu01 Polyclonal Antibody to Paraoxonase 1 (PON1) WB; IHC; ICC; IP.
PAA243Mu02 Polyclonal Antibody to Paraoxonase 1 (PON1) WB; IHC; ICC; IP.
LAA243Mu71 Biotin-Linked Polyclonal Antibody to Paraoxonase 1 (PON1) WB; IHC; ICC.
Assay Kits SEA243Mu ELISA Kit for Paraoxonase 1 (PON1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA243Ra01 Recombinant Paraoxonase 1 (PON1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA243Ra03 Recombinant Paraoxonase 1 (PON1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA243Ra04 Recombinant Paraoxonase 1 (PON1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA243Ra02 Recombinant Paraoxonase 1 (PON1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA243Ra01 Polyclonal Antibody to Paraoxonase 1 (PON1) WB; IHC; ICC; IP.
LAA243Ra71 Biotin-Linked Polyclonal Antibody to Paraoxonase 1 (PON1) WB; IHC; ICC.
MAA243Ra21 Monoclonal Antibody to Paraoxonase 1 (PON1) WB; IHC; ICC; IP.
LAA243Ra51 APC-Linked Polyclonal Antibody to Paraoxonase 1 (PON1) WB; IHC; ICC; IF.
PAA243Ra02 Polyclonal Antibody to Paraoxonase 1 (PON1) WB; IHC; ICC; IP.
Assay Kits SEA243Ra ELISA Kit for Paraoxonase 1 (PON1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence."Biochemistry 30:10141-10149(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position 191, for the respective A or B allozymes."Am. J. Hum. Genet. 52:598-608(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Studies on human serum paraoxonase/arylesterase."Chem. Biol. Interact. 87:25-34(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Human and rabbit paraoxonases: purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification."Chem. Biol. Interact. 87:35-48(1993) [PubMed] [Europe PMC] [Abstract]
  5. "Structural organization of the human PON1 gene."Genomics 35:586-589(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Differential expression of a cDNA clone in human liver versus hepatic cancer -- highly homologous to aryl-dialkyl-phosphatase."Cell Res. 7:79-90(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of a distinct human high-density lipoprotein subspecies defined by a lipoprotein-associated protein, K-45. Identity of K-45 with paraoxonase."Eur. J. Biochem. 211:871-879(1993) [PubMed] [Europe PMC] [Abstract]
  12. "Apolipoprotein J is associated with paraoxonase in human plasma."Biochemistry 33:832-839(1994) [PubMed] [Europe PMC] [Abstract]
  13. "Purification of rabbit and human serum paraoxonase."Biochemistry 30:10133-10140(1991) [PubMed] [Europe PMC] [Abstract]
  14. "Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities."Drug Metab. Dispos. 19:100-106(1991) [PubMed] [Europe PMC] [Abstract]
  15. "Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase."Proc. Natl. Acad. Sci. U.S.A. 92:7187-7191(1995) [PubMed] [Europe PMC] [Abstract]
  16. "Human serum paraoxonase/arylesterase's retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids: apolipoprotein A-I stabilizes activity."Arterioscler. Thromb. Vasc. Biol. 19:2214-2225(1999) [PubMed] [Europe PMC] [Abstract]
  17. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities."J. Lipid Res. 46:1239-1247(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Serendipitous discovery and X-ray structure of a human phosphate binding apolipoprotein."Structure 14:601-609(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  23. "Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes."Nat. Struct. Mol. Biol. 11:412-419(2004) [PubMed] [Europe PMC] [Abstract]
  24. "The molecular basis of the human serum paraoxonase activity polymorphism."Nat. Genet. 3:73-76(1993) [PubMed] [Europe PMC] [Abstract]
  25. "A variant of paraoxonase (PON1) gene is associated with diabetic retinopathy in IDDM."J. Clin. Endocrinol. Metab. 83:2589-2592(1998) [PubMed] [Europe PMC] [Abstract]
  26. "New paraoxonase 1 polymorphism I102V and the risk of prostate cancer in Finnish men."J. Natl. Cancer Inst. 95:812-818(2003) [PubMed] [Europe PMC] [Abstract]
  27. "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract]