Immunoglobulin G4 (IgG4)

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IGHG4; Ig Gamma-4 Chain C Region; Immunoglobulin Heavy Constant Gamma 4; G4m Marker; Immunoglobulin Gm4

Immunoglobulin G4 (IgG4)

Three closely linked loci (IgG1, IgG2 and IgG3) were thought to be responsible for the Gm specificities. Van Loghem et al. (1970) presented evidence on the linkage relationship of immunoglobulin markers (gamma 1, 2, 3, Am).  A fourth IgG locus (gamma-G4) was identifiable in the cluster. Using a gamma-4 probe, Kirsch et al. (1982) assigned the IGH cluster to 14q32 by in situ hybridization. Bech-Hansen et al. (1983) found that an RFLP produced by BamHI is a marker for the heavy chain genes G2 and G4 and a gamma-pseudogene. Considerable linkage disequilibrium was found. Quantitative assessment of the degree of association between C-gamma RFLPs, Gm markers, and switch region RFLPs adjacent to C-mu and C-alpha-1 showed that the gamma-pseudogene is most tightly associated with G2, suggesting that it lies between A1 and G2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPA234Hu01 Native Immunoglobulin G4 (IgG4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA234Hu01 Recombinant Immunoglobulin G4 (IgG4) Positive Control; Immunogen; SDS-PAGE; WB.
CPA234Hu21 OVA Conjugated Immunoglobulin G4 (IgG4) Immunogen; SDS-PAGE; WB.
CPA234Hu31 KLH Conjugated Immunoglobulin G4 (IgG4) Immunogen; SDS-PAGE; WB.
Antibodies PAA234Hu01 Polyclonal Antibody to Immunoglobulin G4 (IgG4) WB; IHC; ICC; IP.
LAA234Hu71 Biotin-Linked Polyclonal Antibody to Immunoglobulin G4 (IgG4) WB; IHC; ICC.
LAA234Hu81 FITC-Linked Polyclonal Antibody to Immunoglobulin G4 (IgG4) WB; IHC; ICC; IF.
MAA234Hu21 Monoclonal Antibody to Immunoglobulin G4 (IgG4) WB; IHC; ICC; IP.
PAA234Hu02 Polyclonal Antibody to Immunoglobulin G4 (IgG4) WB; IHC; ICC; IP.
PAA234Hu03 Polyclonal Antibody to Immunoglobulin G4 (IgG4) WB; IHC; ICC; IP.
LAA234Hu72 Biotin-Linked Monoclonal Antibody to Immunoglobulin G4 (IgG4) WB; IHC; ICC.
LAA234Hu82 FITC-Linked Monoclonal Antibody to Immunoglobulin G4 (IgG4) WB; IHC; ICC; IF.
Assay Kits SEA234Hu ELISA Kit for Immunoglobulin G4 (IgG4) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Nucleotide sequence of a human immunoglobulin C gamma 4 gene."DNA 1:11-18(1981) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Human immunoglobulin subclasses. Partial amino acid sequence of the constant region of a gamma 4 chain."Biochem. J. 117:33-47(1970) [PubMed] [Europe PMC] [Abstract]
  4. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  5. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]